Efficacy of antibiotic-impregnated shunt versus conventional shunts to reduce cerebrospinal fluid infections in children: A systematic review and meta-analysis
| Autor: | Yonglin Wu, Yanzhao Qiu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty MEDLINE Cochrane Library law.invention cerebrospinal fluid infection 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) Randomized controlled trial law Internal medicine medicine antibiotic-impregnated shunt business.industry General Medicine Articles medicine.disease Hydrocephalus meta-analysis 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis Relative risk Observational study conventional shunts business Shunt (electrical) |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Hydrocephalus is among the most common pediatric conditions treated by neurosurgeons. An antibiotic-impregnated shunt (AIS) was designed to reduce the rate of shunt infections. The objective of this systematic review and meta-analysis was to assess the efficiency of AIS in reducing the rate of shunt infection compared with standard shunts (SSs). A systematic search of PubMed, EMBASE, Medline, Cochrane Library, TRIP Database, CINAHL and Google Scholar databases was performed. Eligible studies included observational studies and randomized controlled trials (RCT) that compared the effects of AIS and SS for preventing shunt infections in pediatric patients. Twelve observational studies and one RCT conducted from January 2005 through October 2019 involving 7,952 pediatric patients were included in the analysis. The use of AIS significantly decreased the risk of CRI [risk ratio (RR) 0.42; 95% confidence interval: 0.33 to 0.53; P |
| Databáze: | OpenAIRE |
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