Biological Properties of the Encapsulated Staphylococcus aureus M
| Autor: | Deng-Fong Liau, John H. Hash, M. Ann Melly, Linda J. Duke |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1974 |
| Předmět: |
Phagocytosis
Staphylococcus Immunology Virulence Biology medicine.disease_cause Microbiology Mice Agglutination Tests medicine Animals Opsonin Toxins Biological Bacteriological Techniques Strain (chemistry) Bacterial and Mycotic Infections Opsonin Proteins Culture Media Bacterial vaccine Agglutination (biology) Microscopy Electron Infectious Diseases Staphylococcus aureus Antibody Formation Bacterial Vaccines Mutation Parasitology Immunization Rabbits Immunity Maternally-Acquired |
| Popis: | Strain M, classified as a Staphylococcus aureus , behaves like the other rare encapsulated staphylococcal strains. It was clumping-factor negative, grew in diffuse-type colonies in serum-soft agar, and produced rapidly fatal disease in mice. Strain M was highly resistant to phagocytosis by human or mouse leukocytes and required both specific antibody and heat-labile serum factor(s) for efficient ingestion by human polymorphonuclear leukocytes. Electron micrographs confirmed the presence of a large capsule. Agglutination studies, active or passive mouse protection experiments, and opsonic studies revealed that strain M represents a new, immunologically distinct strain of encapsulated staphylococcus. Strain M differs from other known encapsulated staphylococci in several other respects: its cellular and colonial morphology is atypical; its LD 50 in the mouse peritoneal model is 100 times less than that of other mouse lethal strains; it is poorly opsonized by normal human serum; and, finally, it possesses an unusually large capsule as seen in electron micrographs. |
| Databáze: | OpenAIRE |
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