Reciprocal connectivity between secondary auditory cortical field and amygdala in mice

Autor:	Nana Nishio, Hiroaki Tsukano, Masao Horie, Ryuichi Hishida, Sayaka Sugiyama, Akiyoshi Kakita, Kuniyuki Takahashi, Katsuei Shibuki, Xubin Hou, Hirohide Takebayashi, Hiroki Kitaura
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine Male lcsh:Medicine Biology medicine.disease_cause Auditory cortex Amygdala Neural circuits complex mixtures Article 03 medical and health sciences Mice 0302 clinical medicine Optical imaging Neural Pathways medicine Animals Axon lcsh:Science Auditory Cortex Neurons Multidisciplinary Cholera toxin Cortical field Optical Imaging lcsh:R 030104 developmental biology medicine.anatomical_structure nervous system embryonic structures Cortex Flavoprotein fluorescence lcsh:Q Neuroscience 030217 neurology & neurosurgery psychological phenomena and processes
Zdroj:	Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) Scientific Reports
ISSN:	2045-2322
Popis:	Recent studies have examined the feedback pathway from the amygdala to the auditory cortex in conjunction with the feedforward pathway from the auditory cortex to the amygdala. However, these connections have not been fully characterized. Here, to visualize the comprehensive connectivity between the auditory cortex and amygdala, we injected cholera toxin subunit b (CTB), a bidirectional tracer, into multiple subfields in the mouse auditory cortex after identifying the location of these subfields using flavoprotein fluorescence imaging. After injecting CTB into the secondary auditory field (A2), we found densely innervated CTB-positive axon terminals that were mainly located in the lateral amygdala (La), and slight innervations in other divisions such as the basal amygdala. Moreover, we found a large number of retrogradely-stained CTB-positive neurons in La after injecting CTB into A2. When injecting CTB into the primary auditory cortex (A1), a small number of CTB-positive neurons and axons were visualized in the amygdala. Finally, we found a near complete absence of connections between the other auditory cortical fields and the amygdala. These data suggest that reciprocal connections between A2 and La are main conduits for communication between the auditory cortex and amygdala in mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c9113604ff8c30e758605b0d19e0f7 http://link.springer.com/article/10.1038/s41598-019-56092-9 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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