Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats
| Autor: | Hafez R. Madkor, Sherif W. Mansour, Gamal Ramadan |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty medicine.medical_treatment Lipoproteins Intraperitoneal injection Medicine (miscellaneous) Ginger medicine.disease_cause Plant Roots Lipid peroxidation chemistry.chemical_compound Random Allocation Curcuma Diabetes mellitus Internal medicine medicine Animals Hypoglycemic Agents Rats Wistar Spices Garlic Hypolipidemic Agents Nutrition and Dietetics biology business.industry Insulin medicine.disease Streptozotocin biology.organism_classification Glutathione Lipids Rats B vitamins Oxidative Stress Endocrinology Cholesterol chemistry Diabetes Mellitus Type 2 Liver business Oxidative stress medicine.drug Phytotherapy |
| Zdroj: | The British journal of nutrition. 105(8) |
| ISSN: | 1475-2662 |
| Popis: | Spices which show hypoglycaemic, hypolipidaemic and antioxidant activities may have a role in the treatment of diabetes and its complications. The present study aimed to compare the modulatory effects of garlic, ginger, turmeric and their mixture on the metabolic syndrome and oxidative stress in streptozotocin (STZ)–nicotinamide diabetic rats. Diabetes was induced in overnight fasted rats by a single intraperitoneal injection of STZ (65 mg/kg body weight) and nicotinamide (110 mg/kg body weight, 15 min before STZ injection). Diabetic rats orally received either distilled water (as vehicle) or 200 mg/kg body weight of garlic bulb, ginger rhizome or turmeric rhizome powder suspension separately or mixed together (GGT mixture) for twenty-eight consecutive days. The results showed that these spices and their mixture significantly alleviated (80–97 %,P |
| Databáze: | OpenAIRE |
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