On-Site Quantification and Infection Risk Assessment of Airborne SARS-CoV-2 Virus Via a Nanoplasmonic Bioaerosol Sensing System in Healthcare Settings

Autor: Qiu, Guangyu, Spillmann, Martin, Tang, Jiukai, Zhao, Yi-Bo, Tao, Yile, Zhang, Xiaole, Geschwindner, Heike, Saleh, Lanja, Zingg, Walter, Wang, Jing
Přispěvatelé: University of Zurich, Zingg, Walter, Wang, Jing
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Advanced Science, 9 (35)
ISSN: 2198-3844
Popis: On-site quantification and early-stage infection risk assessment of airborne severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with high spatiotemporal resolution is a promising approach for mitigating the spread of coronavirus disease 2019 (COVID-19) pandemic and informing life-saving decisions. Here, a condensation (hygroscopic growth)-assisted bioaerosol collection and plasmonic photothermal sensing (CAPS) system for on-site quantitative risk analysis of SARS-CoV-2 virus-laden aerosols is presented. The CAPS system provided rapid thermoplasmonic biosensing results after an aerosol-to-hydrosol sampling process in COVID-19-related environments including a hospital and a nursing home. The detection limit reached 0.25 copies/µL in the complex aerosol background without further purification. More importantly, the CAPS system enabled direct measurement of the SARS-CoV-2 virus exposures with high spatiotemporal resolution. Measurement and feedback of the results to healthcare workers and patients via a QR-code are completed within two hours. Based on a dose-responseµ model, it is used the plasmonic biosensing signal to calculate probabilities of SARS-CoV-2 infection risk and estimate maximum exposure durations to an acceptable risk threshold in different environmental settings.
Advanced Science, 9 (35)
ISSN:2198-3844
Databáze: OpenAIRE
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