Helicobacter pylorimultiplex serology and risk of non-cardia and cardia gastric cancer: a case-cohort study and meta-analysis

Autor: Yao, P, Kartsonaki, C, Butt, J, Jeske, R, de Martel, C, Plummer, M, Guo, Y, Clark, S, Walters, RG, Chen, Y, Avery, D, Lv, J, Yu, C, Wang, H, Hill, M, Peto, R, Li, L, Waterboer, T, Chen, Z, Millwood, IY, Yang, L
Rok vydání: 2023
Předmět:
Zdroj: International Journal of Epidemiology.
ISSN: 1464-3685
0300-5771
DOI: 10.1093/ije/dyad007
Popis: BackgroundHelicobacter pylori infection is a major cause of non-cardia gastric cancer (NCGC), but uncertainty remains about the associations between sero-positivity to different H. pylori antigens and risk of NCGC and cardia gastric cancer (CGC) in different populations.MethodsA case-cohort study in China included ∼500 each of incident NCGC and CGC cases and ∼2000 subcohort participants. Sero-positivity to 12 H. pylori antigens was measured in baseline plasma samples using a multiplex assay. Hazard ratios (HRs) of NCGC and CGC for each marker were estimated using Cox regression. These were further meta-analysed with studies using same assay.ResultsIn the subcohort, sero-positivity for 12 H. pylori antigens varied from 11.4% (HpaA) to 70.8% (CagA). Overall, 10 antigens showed significant associations with risk of NCGC (adjusted HRs: 1.33 to 4.15), and four antigens with CGC (HRs: 1.50 to 2.34). After simultaneous adjustment for other antigens, positive associations remained significant for NCGC (CagA, HP1564, HP0305) and CGC (CagA, HP1564, HyuA). Compared with CagA sero-positive only individuals, those who were positive for all three antigens had an adjusted HR of 5.59 (95% CI 4.68–6.66) for NCGC and 2.17 (95% CI 1.54–3.05) for CGC. In the meta-analysis of NCGC, the pooled relative risk for CagA was 2.96 (95% CI 2.58–3.41) [Europeans: 5.32 (95% CI 4.05–6.99); Asians: 2.41 (95% CI 2.05–2.83); PheterogeneityConclusionsSero-positivity to several H. pylori antigens was significantly associated with an increased risk of NCGC and CGC, with varying effects between Asian and European populations.
Databáze: OpenAIRE
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