Cytotoxicity of diplodiatoxin, dipmatol and diplonine, metabolites synthesized by Stenocarpella maydis
| Autor: | C.J. Botha, Mxolisi Goodwill Masango, Gezina Catharina Helena Ferreira, Esam E. Elgorashi, Charlotte Elizabeth Ellis |
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| Rok vydání: | 2013 |
| Předmět: |
Cyclopropanes
Cell Survival Guinea Pigs Stenocarpella maydis CHO Cells Toxicology Zea mays Cell Line Mice Necrosis Cricetulus Dogs Ascomycota Cricetinae Cytotoxic T cell Animals MTT assay Diplodiatoxin Cytotoxicity Plant Diseases biology Chemistry Succinate dehydrogenase Molecular biology Mitochondria Succinate Dehydrogenase Cell culture Chromones Toxicity biology.protein |
| Zdroj: | Toxicon : official journal of the International Society on Toxinology. 82 |
| ISSN: | 1879-3150 |
| Popis: | The cytotoxicity of three Stenocarpella maydis metabolites (diplodiatoxin, dipmatol and diplonine) was investigated on Neuro-2a, CHO-K1 and MDBK cell lines. Diplodiatoxin was the most cytotoxic followed by dipmatol. Conversely, diplonine was not cytotoxic. Diplodiatoxin and dipmatol affected mitochondrial succinate dehydrogenase (MTT assay) and the overall viability of cells as assessed in real-time (xCELLigence assay). The results obtained so far indicate that diplodiatoxin and dipmatol exert their toxicity possibly via the necrotic cell death pathway. |
| Databáze: | OpenAIRE |
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