c-kitExpression and mutations in peripheral T cell lymphomas, except for extra-nodal NK/T cell lymphomas

Autor:	Jong Gwang Kim, Jin Ho Baek, Tae In Park, Young Rok Do, Yee Soo Choe, Hong Suk Song, Ki Young Kwon, Kyu Bo Lee, Myung Hoon Lee, Sang Kyun Sohn, Dong Hwan Kim
Rok vydání:	2006
Předmět:	Adult Male Cancer Research Pathology medicine.medical_specialty T cell Biology Lymphoma T-Cell medicine.disease_cause DNA sequencing Exon medicine Humans Aged Oligonucleotide Array Sequence Analysis Mutation Gene Expression Regulation Leukemic Reverse Transcriptase Polymerase Chain Reaction Gene Expression Profiling Lymphoma T-Cell Peripheral Exons Hematology Middle Aged medicine.disease Immunohistochemistry Molecular biology Peripheral T-cell lymphoma Peripheral Killer Cells Natural Proto-Oncogene Proteins c-kit Imatinib mesylate medicine.anatomical_structure Oncology Female Lymph Nodes
Zdroj:	Leukemia & Lymphoma. 47:267-270
ISSN:	1029-2403 1042-8194
Popis:	The present study evaluated the expression and mutations of c-kit in peripheral T-cell lymphomas (PTCLs), except for extra-nodal NK/T cell lymphomas, as a potential target for treatment with imatinib mesylate. Fifty-two patients diagnosed with PTCLs (peripheral T-cell lymhoma, unspecified, 38 cases; angioimmunoblastic T-cell, 7 cases; anaplastic large cell, 7 cases) were enrolled. The immunohistochemistry was performed using standard procedures with anti-c-kit monoclonal IgG, while the c-kit mutations were analysed on paraffin-embedded specimens using PCR-single-stranded conformational polymorphism followed by direct DNA sequencing. The median age of the patients was 52 years (19 to approximately 75 years) with a male-to-female ratio of 69%:31%. Weak expression of c-kit was found in 16 (30.8%) patients, while only 3 (5.8%) patients exhibited mutations in exon 11 or exon 13. The c-kit mutations in exon 11 occurred at codon 558 (AAG --TAG; Lys --Stop) and at codon 571 (CTA --ATA; Leu --Ile), respectively, while the mutation in exon 13 occurred at codon 634 (CGG --CGA; Arg --Arg). The current study only found c-kit mutations in a few patients with PTCLs, except for extra-nodal NK/T cell lymphomas. Therefore, c-kit would not seem to be a good target for a new therapeutic approach to PTCLs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c6c52e9ecd06342184da14141b682b https://doi.org/10.1080/10428190500281680 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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