Potential hepatoprotective effects of flavonoids contained in propolis from South Sulawesi against chemotherapy agents
| Autor: | Ahmed Gaber, Walaa F. Alsanie, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Muhamad Sahlan, Apriliana Cahya Khayrani, Samy Sayed, Kenny Lischer, Nur Rizka Alia Hapsari, Kartika Diah Pratami, Alaa Alhazmi, Abdullah F. Shater |
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| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
medicine.medical_treatment Flavonoid medicine.disease_cause Propolis chemistry.chemical_compound polycyclic compounds medicine Chemotherapy Doxorubicin Epirubicin chemistry.chemical_classification Traditional medicine Chemistry food and beverages Hepatoprotective carbohydrates (lipids) Polyphenol Original Article General Agricultural and Biological Sciences Quercetin Oxidative stress medicine.drug |
| Zdroj: | Saudi Journal of Biological Sciences |
| ISSN: | 1319-562X |
| Popis: | The use of doxorubicin and epirubicin as chemotherapy agent causes side effects such as liver damage due to oxidative stress by reactive oxygen species (ROS) that cause increased of ALT and AST level as liver parameter. One source of natural antioxidants as ROS neutralizer comes from flavonoid that contain in propolis. Most researchers claim that flavonoid can be used to protect the liver. The aim of this study was to test the hepatoprotective effect of flavonoid in propolis from South Sulawesi against doxorubicin and epirubicin. The experiment included male Sprague dawley rats divided into nine groups. The rats received the microcapsule propolis or the quercetin orally for 15 days. The hepatotoxicity was promoted by injection epirubicin and doxorubicin (i.v.) with a cumulative dose of 9 mg/kg. In this study, total polyphenol and flavonoid tests of propolis have been carried out, there were 1.1% polyphenols and 2.7% flavonoids, the antioxidant activity tests showed IC50 value of 9849 ppm and LCMS/MS tests supported the presence of phenolic compounds in propolis from South Sulawesi. Liver parameter was measured and the results showed that the propolis 200 mg/kg group produced the lowest ALT and had potential protective effect against doxorubicin and epirubicin-induced hepatotoxicity. |
| Databáze: | OpenAIRE |
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