Vitamin D-Dependent Rickets: Eight Cases
| Autor: | Sevil Arı Yuca, Haluk Dülger, Cahide Yılmaz, M. Selçuk Bektaş, Yaşar Cesur, Hayrettin Temel |
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| Přispěvatelé: | CESUR, Yaşar, Selçuk Üniversitesi |
| Rok vydání: | 2016 |
| Předmět: |
Vitamin
medicine.medical_specialty Calcitriol Parathyroid hormone chemistry.chemical_element 030209 endocrinology & metabolism Rickets vitamin D Calcium 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Vitamin D and neurology Hypocalcaemia child business.industry 05 social sciences 050301 education General Medicine medicine.disease Endocrinology chemistry Alkaline phosphatase business 0503 education medicine.drug Eight Cases- EUROPEAN JOURNAL OF GENERAL MEDICINE cilt.13 ss.16-20 2016 [Cesur Y. Yuca S. A. Bektas S. Yilmaz C. Dulger H. Temel H. -Vitamin D-Dependent Rickets] |
| Popis: | WOS: 000382752700003 Objective: Vitamin D is essential for bone development and health, and deficiency resulting in rickets and skeletal deformities is seen mainly during rapid growth. Hereditary vitamin D dependent rickets type I and type II rickets is a very rare form of rickets, characterized by 1-alpha-hydroxylase deficiency or end-organ resistance to vitamin D. We aimed to investigate, clinical and laboratory characteristics of eight cases with Vitamin D-dependent rickets (VDRR). Method: The mean age of patients during diagnosis was 2.6 years. Excluding one patient, others were males (87.5%). Results: Mean laboratory values during referral was calcium 7.5 +/- 1,5 mg/dl, phosphorus 4 +/- 1.2 mg/dl, alkaline phosphatase (ALP) 1679 +/- 641 U/L and parathyroid hormone (PTH) 524 +/- 498 pg/ml. Patients received 1.2 mu g/kg/day calcitriol. During follow-ups serum ALP and PTH values of patients turned to normal levels. Conclusion: In rickets, cases with persistent increased serum ALP and PTH levels it will be appropriate to investigate serum 25 (OH) D levels in cases diagnosed with vitamin D-dependent rickets even though hypocalcaemia is absent. Administration of adequate doses of calcitriol in some cases is able to clinical and laboratory values return to normal. |
| Databáze: | OpenAIRE |
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