Effects of Dietary Omega-3 Fatty Acid Supplementation on Endothelium-Dependent Vasodilation in Patients With Chronic Heart Failure
| Autor: | Lana J. Dixon, G. Dennis Johnston, Lawrence T. McGrath, Naglaa A. El-Sherbeeny, Paul Hamilton, William J. Leahey, C G Hanratty, David R. Morgan, Gary E. McVeigh |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Nitroprusside medicine.medical_specialty Diet therapy Arbitrary unit Vasodilation Double-Blind Method Internal medicine Fatty Acids Omega-3 medicine Humans Plant Oils Olive Oil Aged Endothelium-Dependent Relaxing Factors Heart Failure chemistry.chemical_classification Cross-Over Studies business.industry Angiotensin II Fatty acid Crossover study Acetylcholine Plethysmography Forearm NG-Nitroarginine Methyl Ester Endocrinology chemistry Docosahexaenoic acid Dietary Supplements Female Sodium nitroprusside Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | The American Journal of Cardiology. 97:547-551 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2005.08.075 |
| Popis: | We investigated the effects of omega-3 fatty acids administration on endothelium-dependent vasodilation in patients > or =65 years old who received treatment for chronic heart failure (CHF). Twenty patients (mean age 73 years; 15 men) with grade II and III CHF who were on maximal medical management were recruited. Patients were randomized in a double-blind, crossover fashion to 6 weeks of omega-3 fatty acid (1.8 g ecosapentaenoic acid and 1.2 g docosahexaenoic acid) or olive oil. Forearm blood flow (FBF) responses to incremental doses of intra-arterial sodium nitroprusside, acetycholine (ACH), angiotensin-II, and N(g)-nitro-L-arginine methyl ester were assessed by venous occlusion strain gauge plethysmography. The endothelium-dependent increase in FBF was greater in response in ACH infusion after omega-3 fatty acid administration (7.9, 95% confidence interval [CI] 4.81 to 11.08 to 11.3, 95% CI 7.31 to 15.23 arbitrary units (p |
| Databáze: | OpenAIRE |
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