A discernable increase in the severe acute respiratory syndrome coronavirus 2 R.1 lineage carrying an E484K spike protein mutation in Japan
| Autor: | Kazuhiro Okubo, Asami Ohnishi, Keiko Goto, Kentaro Itokawa, Masanori Hashino, Hiroyuki Tsukagoshi, Makoto Ohnishi, Hayato Ehara, Tsuyoshi Sekizuka, Makoto Kuroda, Ryohei Nomoto |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Lineage (genetic) Coronavirus disease 2019 (COVID-19) Short Communication Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mutant R.1 Spike protein Biology medicine.disease_cause Microbiology Genome Spatiotemporal distribution Japan Genetics medicine Humans Molecular Biology Ecology Evolution Behavior and Systematics Whole genome sequencing Mutation Whole Genome Sequencing SARS-CoV-2 Immune escape E484K COVID-19 Spike Protein Infectious Diseases Mutation (genetic algorithm) Spike Glycoprotein Coronavirus Mutation of concern |
| Zdroj: | Infection, Genetics and Evolution |
| ISSN: | 1567-1348 |
| DOI: | 10.1016/j.meegid.2021.105013 |
| Popis: | Three COVID-19 waves in Japan have been characterized by the presence of distinct PANGO lineages (B.1.1. 162, B.1.1.284, and B.1.1.214). Recently, in addition to the B.1.1.7 lineage, which shows 25% abundance, an R.1 lineage carrying the E484K mutation in the spike protein was found to show up to 40% predominance. E484K could be a pivotal amino acid substitution with the potential to mediate immune escape; thus, more attention should be paid to such potential variants of concern to avoid the emergence of mutants of concern. Such comprehensive real-time genome surveillance has become essential for the containment of COVID-19 clusters. |
| Databáze: | OpenAIRE |
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