Relevance of Sensitivity Testings (MIC) of S. aureus to Predict the Antibacterial Action in Milk
| Autor: | M. Louhi, V. Myllys, K. Inkinen, M. Sandholm |
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| Rok vydání: | 1992 |
| Předmět: |
Staphylococcus aureus
medicine.drug_class Antibiotics Microbial Sensitivity Tests Biology medicine.disease_cause Microbiology Enrofloxacin medicine Animals Mastitis Bovine Antibacterial agent Dose-Response Relationship Drug General Medicine Staphylococcal Infections biochemical phenomena metabolism and nutrition Anti-Bacterial Agents Penicillin Milk Vancomycin Cattle Female Gentamicin Ceftiofur medicine.drug |
| Zdroj: | Journal of Veterinary Medicine, Series B. 39:253-262 |
| ISSN: | 1439-0450 0931-1793 |
| Popis: | Summary Bacterial susceptibility testings were carried out in parallel Iso-sensitest broth (ISB) and bovine milk cultures using 16 antibacterials and 4 sensitive strains of mastitic isolates of Staphylococcus aureus. Bacterial activities were analyzed by continuous turbidity monitoring (broth cultures), continuous fluorometric monitoring of the resazurin-reducing redox activity, and by analyzing the triphenyltetra-zolium (TTC)-reducing capacity at the end of the incubation period. To obtain an equipotent bacteria-suppressing activity, milk cultures required in general several times more antibiotic than the respective ISB cultures. Antibacterial activities of sulfadoxine-trimethoprim, vancomycin, novobiocin, macrolides, aminoglycosides and oxytetracycline were most effectively suppressed by milk. Aminoglycosides suffered additionally from reduction of oxygen in the incubation environment. The s-lactams (penicillin G, oxacillin, cephalothin, ceftiofur, ampicillin, ampicillin-clavulanic acid), gentamicin and enrofloxacin showed extremely variable sensitivity results depending on the S. aureus/milk combination. |
| Databáze: | OpenAIRE |
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