Sodium Cromoglycate Decreases Sensorimotor Impairment and Hippocampal Alterations Induced by Severe Traumatic Brain Injury in Rats
| Autor: | Sandra Orozco-Suárez, Marysol Segovia-Oropeza, Luisa Rocha, Cindy Santiago-Castañeda, Luis Concha |
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| Rok vydání: | 2020 |
| Předmět: |
Male
030506 rehabilitation Traumatic brain injury Hippocampus Motor Activity Hippocampal formation Pharmacology Neuroprotection 03 medical and health sciences 0302 clinical medicine Brain Injuries Traumatic Cromolyn Sodium medicine Animals Rats Wistar business.industry medicine.disease Rats Neuroprotective Agents nervous system Sodium cromoglycate Immunohistochemistry Neurology (clinical) Animal studies 0305 other medical science business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurotrauma. 37:2595-2603 |
| ISSN: | 1557-9042 0897-7151 |
| Popis: | Severe traumatic brain injury (TBI) results in significant functional disturbances in the hippocampus. Studies support that sodium cromoglycate (CG) induces neuroprotective effects. This study focused on investigating the effects of post-TBI subchronic administration of CG on hippocampal hyperexcitability and damage as well as on sensorimotor impairment in rats. In contrast to the control group (Sham+SS group), animals undergoing severe TBI (TBI+SS group) showed sensorimotor dysfunction over the experimental post-TBI period (day 2, 55% |
| Databáze: | OpenAIRE |
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