Isolation of measles virus below 4 months of age during an outbreak in Pune, India

Autor:	Kalyan Banerjee, Niteen Wairagkar, Naseem Shaikh, P Udavant
Rok vydání:	1998
Předmět:	Pediatrics medicine.medical_specialty Measles Vaccine Population India Measles Disease Outbreaks Measles virus Morbillivirus Humans Medicine Risk factor education Mononegavirales education.field_of_study biology business.industry Vaccination Age Factors Infant Outbreak Orphanages General Medicine biology.organism_classification medicine.disease Immunology business
Zdroj:	The Lancet. 351:495-496
ISSN:	0140-6736
DOI:	10.1016/s0140-6736(05)78682-7
Popis:	This article reports the isolation of a measles virus from infants under 4 months of age during an outbreak in an orphanage at Pune, India, in 1996. With a total population of 24 orphanages, 6 inmates showed the signs and symptoms of measles; 4 were under 4 months old and the other 2 were 7 and 11 months old, respectively. Bronchopneumonia and weight loss were observed as the main complications of the disease. Isolation of the measles virus was done by obtaining throat swabs, skin scrapings, and blood samples from the victims. Serum testing of the 6 cases showed a positive result for immunoglobulin M (IgM) antibodies. During the same period, mothers of 4 IgM-positive infants were screened for antibodies; 3 mothers were negative for measles-specific antibodies. Because of this, lack of maternal antibodies, malnutrition, and crowding were accounted for the outbreak of measles in the orphanage. These findings reflect a need to assess the prevalence of measles within this age group and develop prevention strategies for measles.
Databáze:	OpenAIRE
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