Interleukin-10 -1082 Gene Polymorphism and Susceptibility to Cervical Cancer Among Japanese Women
| Autor: | Koji Matsumoto, Satoshi Okada, Akinori Oki, Manabu Sakurai, Takeo Minaguchi, Mamiko Onuki, Toyomi Satoh, Hiroyuki Ochi, Hiroyuki Yoshikawa, Azusa Abe, Hiromi Hamada, Sari Nakao |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Genotype Uterine Cervical Neoplasms Single-nucleotide polymorphism Cervix Uteri Cervical intraepithelial neoplasia Polymerase Chain Reaction Polymorphism Single Nucleotide Asian People Risk Factors Internal medicine Cytology medicine Genetic predisposition Humans Genetic Predisposition to Disease Neoplasm Invasiveness Radiology Nuclear Medicine and imaging Promoter Regions Genetic Papillomaviridae Cervix Cervical cancer business.industry Papillomavirus Infections DNA General Medicine Middle Aged Prognosis Uterine Cervical Dysplasia medicine.disease Interleukin-10 medicine.anatomical_structure Immunology Female Gene polymorphism business |
| Zdroj: | Japanese Journal of Clinical Oncology. 40:1113-1116 |
| ISSN: | 1465-3621 0368-2811 |
| Popis: | Polymorphisms in cytokine genes can influence immune responses to human papillomavirus infection, possibly modifying risks of cervical cancer. Using an amplification refractory mutation system-polymerase chain reaction method, we analyzed a single nucleotide polymorphism (A/G) at position -1082 in interleukin-10 promoter region in 440 Japanese women: 173 women with normal cytology, 163 women with cervical intraepithelial neoplasia and 104 women with invasive cervical cancer. The carrier frequency of interleukin-10 -1082 G alleles associated with higher interleukin-10 production increased with disease severity: 9.8% for normal cytology; 19.6% for cervical intraepithelial neoplasia; 29.8% for invasive cervical cancer (P for trend < 0.001). Among cytologically normal women, human papillomavirus infections were more common in those who were positive for an interleukin-10 -1082 G allele (P = 0.04). In conclusion, our data suggest that interleukin-10 -1082 gene polymorphism may serve as a marker of genetic susceptibility to cervical cancer among Japanese women. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|