Evidence for non-neurotensin receptor-mediated effects of xenin (1–25)—focus on intestinal microcirculation
| Autor: | I Kleiman, Markus Heuser, Stefan Post, O Pöpken, Rainer Nustede |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Erythrocytes Physiology Clinical Biochemistry Ischemia 030209 endocrinology & metabolism Biology Xenin Biochemistry Microcirculation 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Endocrinology medicine.artery Internal medicine medicine Animals Superior mesenteric artery Neurotensin receptor Intestinal Mucosa Rats Wistar Receptor Neurotensin 030304 developmental biology Microscopy 0303 health sciences Anatomy medicine.disease Rats Jejunum chemistry Reperfusion Injury Luminescent Measurements Peptides Blood Flow Velocity Intravital microscopy |
| Zdroj: | Regulatory Peptides. 107:23-27 |
| ISSN: | 0167-0115 |
| DOI: | 10.1016/s0167-0115(02)00062-9 |
| Popis: | Xenin (1-25) has been detected in various locations in mammalians. It has structural similarities with neurotensin and its intestinal effects are claimed to be mediated by neurotensin receptors. It has been shown to influence gastrointestinal motility. The effects of xenin (1-25) on intestinal microvascular perfusion after ischemia/reperfusion have not been investigated yet. Therefore, the superior mesenteric artery was clamped for 40 min in Wistar rats (n=8). Ten minutes prior to reperfusion, intravenous infusion of xenin (1-25) (5 nmol/kg/h) was started. By means of intravital microscopy, microvascular perfusion in the mucosal layer was assessed. Animals (n=8) with and without clamping of the superior mesenteric artery and infusion of the carrier solution served as controls. After ischemia/reperfusion, xenin (1-25) increased the density of perfused microvessels and the capillary red blood cell velocity compared to ischemic controls. Capillary red blood cell velocity was elevated (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect