Adult Pineal Region Atypical Teratoid Rhabdoid Tumor: A Case for Aggressive Surgical and Chemoradiation Management with Comprehensive Literature Review
| Autor: | John F. Berry, Cassidy Werner, Joseph R. Keen, Cuong J. Bui, Mansour Mathkour, Katie Carsky, Christopher Carr, Erin Biro, A. Bert Chabot, Joseph D. Lockwood |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Pineal region Neurosurgical Procedures 03 medical and health sciences 0302 clinical medicine medicine Humans Neoplasm Rhabdoid Tumor Diplopia medicine.diagnostic_test business.industry Teratoma Magnetic resonance imaging Chemoradiotherapy medicine.disease 030220 oncology & carcinogenesis Atypical teratoid rhabdoid tumor Immunohistochemistry Surgery Neurology (clinical) Radiology medicine.symptom Headaches Differential diagnosis business 030217 neurology & neurosurgery |
| Zdroj: | World Neurosurgery. 142:117-127 |
| ISSN: | 1878-8750 |
| Popis: | Background Atypical teratoid rhabdoid tumor (ATRT) is a rare, highly malignant central nervous system neoplasm classified as an embryonal grade IV neoplasm by the World Health Organization. ATRT generally occurs in children younger than 3 years of age with 85 pathologically confirmed cases reported in adults. It is most commonly supratentorial with only 9 confirmed adult cases localized to the pineal region. Case Presentation The authors describe the case of a 29-year-old man with a history of chronic migraines and a previously negative computed tomography (CT) scan of the head presenting with worsening headaches and new onset diplopia with upward gaze palsy. CT and magnetic resonance imaging (MRI) revealed a hemorrhagic pineal mass with extension into the right thalamus. Post resection, the immunohistochemical staining and cytogenetic profile proved consistent with ATRT, making it the ninth reported case of pineal ATRT in an adult which was treated aggressively with good outcome. Conclusion Adult ATRT is rare, especially in the pineal region with only 9 cases reported. Because of the aggressiveness, ATRT must be considered in the differential diagnosis of pineal-region lesions since early diagnosis and aggressive treatment is key to prolonged survival. |
| Databáze: | OpenAIRE |
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