Acute symptomatic seizures secondary to autoimmune encephalitis and autoimmune-associated epilepsy: conceptual definitions
| Autor: | Sarosh R. Irani, Jenny J. Linnoila, Viviana Venegas, Christian G. Bien, Claude Steriade, Avi Gadoth, Xiao Qiu Shao, Russell C. Dale, Jeffrey W. Britton, Andrew McKeon |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Pediatrics medicine.medical_specialty Adolescent Hashimoto Disease medicine.disease_cause Autoimmunity 03 medical and health sciences Epilepsy Young Adult 0302 clinical medicine Seizures medicine Causes of seizures Humans In patient Autoantibodies Autoimmune encephalitis business.industry Autoantibody Symptomatic seizures Middle Aged medicine.disease Pathophysiology 030104 developmental biology Neurology Acute Disease Encephalitis Female Neurology (clinical) business 030217 neurology & neurosurgery Biomarkers |
| DOI: | 10.1111/epi.16571 |
| Popis: | Seizures are a well-recognized and often prominent manifestation of autoimmune encephalitic syndromes. Progress in detection of pathogenic neural autoantibodies has led to increased awareness of autoimmune causes of seizures. Clinical studies of patients with these autoantibodies have improved our understanding of the seizure characteristics, treatments, and seizure prognosis in these disorders. The International League Against Epilepsy (ILAE) Autoimmunity and Inflammation Taskforce proposes conceptual definitions for two main diagnostic entities: (a) acute symptomatic seizures secondary to autoimmune encephalitis, and (b) autoimmune-associated epilepsy, the latter of which suggests an enduring predisposition to seizures. Such a distinction is relevant when discussing the pathophysiology, treatment, prognosis, and social consequences of these disorders. We discuss the role of biomarkers in the application of these conceptual definitions and illustrate their use in patients cared for by members of the task force. |
| Databáze: | OpenAIRE |
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