| Autor: |
Nathaniel Melling, Julia Grass, Matthias Reeh, Michael Tachezy, Marco Blessmann, Felix Nickel, Thilo Hackert, Katharina Grupp |
| Rok vydání: |
2023 |
| Předmět: |
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| Popis: |
Background Prolyl hydroxylase 1 (PHD1) is a prognostic marker in several cancers. Aims and scopes This study was undertaken to elucidate the clinical relevance of PHD1 in colorectal cancer (CRC) prognosis. Materials and methods We compared PHD1 expression on a tissue microarray (TMA) containing samples from 1800 CRCs with corresponding clinicopathological tumor variables and patient survival. Results While PHD1 staining was always high in benign colorectal epithelium, high PHD1 staining was detectable in only 71.8% of CRCs. Low PHD1 staining was associated with advanced tumor stage (p = 0.0101) and shortened overall survival in CRC patients (p = 0.0011). In a multivariable analysis including tumor stage, histological type and PHD1 staining revealed tumor stage and histological type (p p = 0.0202) to be independent prognostic markers for CRC. Conclusions In our cohort, loss of PHD1 expression independently identified a subset of CRC patients with poor overall survival and might, thus, be a promising prognostic marker. PHD1 targeting may even allow for specific therapeutic approaches for these patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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