Arrhythmias in primary hyperparathyroidism evaluated by exercise test

Autor: Salvatore Minisola, Sergio Morelli, Cristiana Cipriani, Elisabetta Romagnoli, Claudia Castro, Sara Piemonte, Marisa Varrenti, Antonella D’Angelo, Marco Colotto, Mario Curione, Jessica Pepe
Přispěvatelé: Pepe, J, Curione, M, Morelli, S, Colotto, M, Varrenti, M, Castro, C, D'Angelo, A, Cipriani, C, Piemonte, S, Romagnoli, E, Minisola, S
Rok vydání: 2012
Předmět:
QT interval
medicine.medical_specialty
endocrine system diseases
Primary hyperparathyroidism
Clinical Biochemistry
Logistic regression
Biochemistry
arrhythmias risk factors
bicycle ergometer exercise test
primary hyperparathyroidism
qt interval
ventricular premature beats
Electrocardiography
Heart Rate
Risk Factors
Internal medicine
Heart rate
medicine
Humans
cardiovascular diseases
Ventricular premature beat
Exercise
Aged
Peak exercise
medicine.diagnostic_test
business.industry
Arrhythmias risk factor
Case-control study
Arrhythmias
Cardiac
General Medicine
Middle Aged
Hyperparathyroidism
Primary
medicine.disease
Postmenopause
Endocrinology
Case-Control Studies
Exercise Test
cardiovascular system
Cardiology
Bicycle ergometer exercise test
Calcium
Female
Ventricular premature beats
Case-Control Studie
business
Human
Zdroj: European Journal of Clinical Investigation. 43:208-214
ISSN: 0014-2972
Popis: Background: Hypercalcemia induces arrhythmias and shortening of QT. The aim of this study was to investigate risk factors for occurrence of arrhythmias in patients with primary hyperparathyroidism (PHPT) during bicycle ergometer exercise test (ET). Methods: Thirty PHPT postmenopausal women (mean age, 60·9 ± 8·0 years) and 30, sex and age-matched, controls underwent ET, echocardiogram and mineral metabolism biochemical evaluation. The following stages were considered during ET: rest, peak exercise, recovery (early recovery, 2 and 10 min after peak exercise). QT was corrected with Bazett's formula (QTc). Results: Compared with controls, PHPT patients showed an increased occurrence of ventricular premature beats (VPBs) during ET (26·6% vs. 6·6%, P = 0·03). Being affected by PHPT predicted the onset of VPBs at peak exercise (P = 0·04) and recovery (P = 0·03), as shown by logistic regression analysis. In PHPT patients, serum calcium level was a predictor of VPBs at peak exercise (P = 0·05). QTc in patients with PHPT was in the normal range. Serum calcium level showed a negative correlation with QTc (P = 0·01) in whole sample. Compared with controls, PHTP patients had QTc significantly shorter for every stage of ET, except at peak exercise. Physiological reduction of QTc interval from rest to peak exercise was not seen in patients with PHPT, QTc at rest being the only predictor of QTc in every stage, as shown by multivariate regression analysis. Conclusions: In patients with PHPT, an increased occurrence of VPBs and a different QTc adaptation during ET were observed and may represent risk factors for major arrhythmias. © 2012 Stichting European Society for Clinical Investigation Journal Foundation.
Databáze: OpenAIRE
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