Imidazoleacetic acid excretion in guinea-pigs adapted to histamine
| Autor: | J. M. Krajewska, C Maślinski |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Aerosols
Male Pharmacology medicine.medical_specialty Histamine N-methyltransferase Inhalation Chemistry Guinea Pigs Imidazoles Oxidative deamination Urine Acetates Excretion chemistry.chemical_compound Endocrinology Pyridoxal Phosphate Internal medicine medicine Animals Female Amine Oxidase (Copper-Containing) Diamine oxidase Pyridoxal phosphate Histamine |
| Zdroj: | European Journal of Pharmacology. 5:213-219 |
| ISSN: | 0014-2999 |
| Popis: | The excretion of imidazoleacetic acid (ImAA) was examined in the urine of guinea-pigs treated daily for 8–12 weeks with histamine aerosols (adapted guinea-pigs). In histamine-adapted animals tested 8 days after the last exposure to histamine aerosol, the urinary excretion of ImAA was higher than in normal ones. However, in contrast to normal animals any additional inhalation of histamine produced a marked decrease in ImAA excretion. The inhibitory action of excessive amounts of histamine on diamine oxidase (DAO) (EC. 1.4.3.6) activity and therefore ImAA excretion may depend on the formation of a condensation product of histamine with pyridoxal phosphate. The role of the inhibitory action of an excess of histamine on the original metabolic pathway of histamine degradation is discussed. |
| Databáze: | OpenAIRE |
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