Synthesis, characterization, cytotoxicity and antibacterial activity of an anthracenyl-linked bis(pyrazolyl)methane ligand and its zinc(II) complexes
| Autor: | Baoan Song, Yupeng Tian, Ban-Feng Ruan, Wan-Ding Liu, Ying-Zhong Zhu |
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| Rok vydání: | 2014 |
| Předmět: |
Models
Molecular Stereochemistry chemistry.chemical_element Antineoplastic Agents Microbial Sensitivity Tests Zinc Crystal structure Crystallography X-Ray Gram-Positive Bacteria Structure-Activity Relationship Cell Line Tumor Gram-Negative Bacteria Drug Discovery Organometallic Compounds Humans Cytotoxic T cell Cytotoxicity Cell Proliferation Antibacterial agent Anthracenes Pharmacology Dose-Response Relationship Drug Molecular Structure biology Chemistry Ligand Organic Chemistry General Medicine biology.organism_classification Pseudomonas putida Anti-Bacterial Agents Pyrazoles Drug Screening Assays Antitumor Antibacterial activity Methane |
| Zdroj: | European Journal of Medicinal Chemistry. 72:46-51 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2013.10.064 |
| Popis: | Three novel Zn(II) complexes (1–3) with 1,1′-(anthracen-9-ylmethylene)bis(1H-pyrazole) (L2) have been prepared and structurally characterized by X-ray crystallography. Among them, 1 is a binuclear Zn(II) complex while 2 and 3 are mononuclear. The in vitro cytotoxic and antibacterial activities of these complexes were also evaluated. The three complexes exhibit cytotoxic specificity and significant antitumor activity. The MIC50 value of complex 1 against Pseudomonas putida reaching 0.011 μg/mL much lower than that the positive control chloromycin (0.182 μg/mL), indicates that complex 1 is a potent antibacterial agent. |
| Databáze: | OpenAIRE |
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