C 21 steroidal glycosides from the roots of Cynanchum paniculatum
| Autor: | Zhifeng Li, Dan Zhao, Shao-Fei Chen, Bao-Min Feng, Xiao-Jie Lu, Xiao An, Yue-Hu Pei, Gang Chen, Xia-Nan Sang, Hai-Feng Wang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Antioxidant
Steroidal glycosides DPPH Stereochemistry medicine.medical_treatment Microbial Sensitivity Tests Cynanchum 010402 general chemistry Plant Roots 01 natural sciences chemistry.chemical_compound Cell Line Tumor Drug Discovery medicine Humans Glycosides Cytotoxicity Pharmacology chemistry.chemical_classification Molecular Structure biology 010405 organic chemistry Chemistry Glycoside General Medicine Cynanchum paniculatum Pregnanes biology.organism_classification Antineoplastic Agents Phytogenic In vitro 0104 chemical sciences |
| Zdroj: | Fitoterapia. 113:51-57 |
| ISSN: | 0367-326X |
| DOI: | 10.1016/j.fitote.2016.07.001 |
| Popis: | As a part of our continuing research for bioactive constituents from Cynanchum plants, four new C21 steroidal glycosides, cynapanoside D-G (1-4), together with six known compounds (5-10) were isolated from the roots of Cynanchum paniculatum (Bge.) Kitag. Their structures were elucidated on the basis of 1D- and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. Compound 8 exhibited potent inhibitory activities against HL-60, HT-29, PC-3 and MCF-7 cell lines with IC50 values of 8.3, 7.5, 34.3 and 19.4μM, respectively and compounds 1-4 and 9 displayed moderate cytotoxicity against the four cell lines. The in vitro antioxidant activities of compounds 1-4, 8 and 9 were assayed by DPPH radical scavenging activity. Antibacterial and antifungal activities of compounds 1-4, 8 and 9 were also tested. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect