Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery

Autor: Battersby, Nick, Glasbey, James C., Neary, Peter, Negoi, Ionut, Kamarajah, Sivesh, Sgro, Alessandro, Bhangu, Aneel, Pinkney, Thomas, Frasson, Matteo, El-Hussuna, Alaa, Battersby, Nick J., Buchs, Nicolas C., Buskens, Christianne, Chaudri, Sanjay, Gallo, Gaetano, Glasbey, James, Minaya-Bravo, Ana María, Morton, Dion, Nepogodiev, Dmitri, Pata, Francesco, Sánchez-Guillén, Luis, Singh, Baljit, Zmora, Oded, Perry, Rita, Magill, Laura, Altomare, Donato, Bemelman, Willem, Brown, Steven, Denost, Quentin, Knowles, Charles, Laurberg, Søren, Lefevre, Jérémie H., Möeslein, Gabriela, Pinkney, Tom, Vaizey, Carolynne, Bilali, S., Bilali, V., Salomon, M., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Farina, P., Carballo, F., Guckenheimer, S., Proud, D., Brouwer, R., Bui, A., Nguyen, B., Smart, P., Warwick, A., Theodore, J. E., Herbst, F., Birsan, T., Dauser, B., Ghaffari, S., Hartig, N., Stift, A., Argeny, S., Unger, L., Strouhal, R., Heuberger, A., Varabei, A., Lahodzich, N., Makhmudov, A., Selniahina, L., Feryn, T., Leupe, T., Maes, L., Reynvoet, E., Van Langenhove, K., Nachtergaele, M., Monami, B., Francart, D., Jehaes, C., Markiewicz, S., Weerts, J., Van Belle, K., Bomans, B., Cavenaile, V., Nijs, Y., Vertruyen, M., Pletinckx, P., Claeys, D., Defoort, B., Muysoms, F., Van Cleven, S., Lange, C., Vindevoghel, K., Wolthuis, A., Todorovic, M., Dabic, S., Kenjic, B., Lovric, S., Vidovic, J., Delibegovic, S., Mehmedovic, Z., Christiano, A., Lombardi, B., Marchiori, M., Tercioti, V., Dardanov, D., Petkov, P., Simonova, L., Yonkov, A., Zhivkov, E., Maslyankov, S., Pavlov, V., Sokolov, M., Todorov, G., Stoyanov, V., Batashki, I., Iarumov, N., Lozev, I., Moshev, B., Slavchev, M., Atanasov, B., Belev, N., Krstev, P., Penkov, R., Šantak, G., Ćosić, J., Previšić, A., Vukušić, L., Zukanović, G., Zelić, M., Kršul, D., Lekić Vitlov, V., Mendrila, D., Orhalmi, J., Dusek, T., Maly, O., Paral, J., Sotona, O., Skrovina, M., Bencurik, V., Machackova, M., Kala, Z., Farkašová, M., Grolich, T., Procházka, V., Hoch, J., Kocian, P., Martinek, L., Antos, F., Pruchova, V., El-Hussuna, A., Ceccotti, A., Madsbøll, T., Straarup, D., Uth Ovesen, A., Christensen, P., Bondeven, P., Edling, P., Elfeki, H., Alexandrovich Gameza, V., Michelsen Bach, S., Zheltiakova, I., Krarup, P. M., Krogh, A., Rolff, H. -C., Lykke, J., Juvik, A. F., Lóven, H. H. K., Marckmann, M., Osterkamp, J. T. F., Madsen, A. H., Worsøe, J., Ugianskis, A., Kjær, M. D., Youn Cho Lee, B., Khalid, A., Kristensen, M. H., El Sorogy, M., Elgeidie, A., Elhemaly, M., El Nakeeb, A., Elrefai, M., Shalaby, M., Emile, S., Omar, W., Sakr, A., Thabet, W., Awny, S., Metwally, I., Refky, B., Shams, N., Zuhdy, M., Lepistö, A., Keränen, I., Kivelä, A., Lehtonen, T., Siironen, P., Rautio, T., Ahonen-Siirtola, M., Klintrup, K., Paarnio, K., Takala, H., Hyöty, M., Haukijärvi, E., Kotaluoto, S. -M., Lehto, K., Tomminen, T., Huhtinen, H., Carpelan, A., Karvonen, J., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Passot, G., D'Alessandro, A., Chouillard, E., Etienne, J. C., Ghilles, E., Vinson-Bonnet, B., Germain, A., Ayav, A., Bresler, L., Chevalier, R., Denost, Q., Didailler, R., Rullier, E., Tiret, E., Chafai, N., Lefevre, J. H., Parc, Y., Sielezneff, I., Mege, D., Lakkis, Z., Barussaud, M., Krones, C., Bock, B., Webler, R., Baral, J., Lang, T., Münch, S., Pullig, F., Schön, M., Hinz, S., Becker, T., Möller, T., Richter, F., Schafmayer, C., Hardt, J., Kienle, P., Crescenti, F., Ahmad, M., Soleiman, Y., Papaconstantinou, I., Gklavas, A., Nastos, K., Theodosopoulos, T., Vezakis, A., Stamou, K., Saridaki, A., Xynos, E., Paraskakis, S., Zervakis, N., Skroubis, G., Amanatidis, T., Germanos, S., Maroulis, I., Papadopoulos, G., Dimitriou, N., Alexandrou, A., Felekouras, E., Griniatsos, J., Karavokyros, I., Papadopoulos, A., Chouliaras, C., Ioannidis, P., Katsounis, D., Kefalou, E., Katsoulis, I. E., Balalis, D., Korkolis, D. P., Manatakis, D., Tzovaras, G., Baloyiannis, I., Mamaloudis, I., Lázár, G., Ábraham, S., Paszt, A., Simonka, Z., Tóth, I., Zaránd, A., Baranyai, Z., Ferreira, G., Harsányi, L., Ónody, P., Banky, B., Burány, Á., Lakatos, M., Marton, J., Solymosi, A., Besznyák, I., Bursics, A., Papp, G., Saftics, G., Svastics, I., Valsdottir, E., Atladottir, J., Jonsson, T., Moller, P., Sigurdsson, H., Gupta, S. K., Gupta, S., Kaul, N., Mohan, S., Sharma, G., Wani, R., Chowdri, N., Khan, M., Mehraj, A., Parray, F. Q., Coveney, A., Burke, J., Deasy, J., El-Masry, S., Mcnamara, D., Khan, M. F., Cahill, R., Faul, E., Mulsow, J., Shields, C., Kelly, M. E., Bass, G., Martin, S. T., O'Connell, R., Ryan, E., Connelly, T., Ahmad, G., Bukhari, W., Cooke, F., Zmora, O., Gold Deutch, R., Haim, N., Lavy, R., Moscovici, A., Shussman, N., Gefen, R., Marom, G., Pikarsky, A., Weiss, D., Avital, S., Hermann, N., Raguan, B., Slavin, M., White, I., Wasserberg, N., Arieli, H., Gurevich, N., Freund, M. R., Dorot, S., Edden, Y., Halfteck, G., Reissman, P., Pery, R., Tulchinsky, H., Weizman, A., Agresta, F., Curinga, R., Finotti, E., Savino, G., Verza, L. A., Asteria, C. R., Boccia, L., Pascariello, A., Tamini, N., Bugatti, A., Gianotti, L., Totis, M., Vincenti, L., Andriola, V., Giannini, I., Travaglio, E., Balestri, R., Buccianti, P., Roffi, N., Rossi, E., Urbani, L., Mellano, A., Cinquegrana, A., Lauretta, A., Belluco, C., Mistrangelo, M., Allaix, M. E., Arolfo, S., Morino, M., Testa, V., Delrio, P., Pace, U., Rega, D., Scala, D., Clerke, C., Clerico, G., Cornaglia, S., Realis Luc, A., Trompetto, M., Ugolini, G., Antonacci, N., Fabbri, S., Montroni, I., Zattoni, D., D'Urbano, C., Cornelli, A., Viti, M., Inama, M., Bacchion, M., Casaril, A., Impellizzeri, H., Moretto, G., Spinelli, A., Carvello, M., David, G., Di Candido, F., Sacchi, M., Frontali, A., Ceriani, V., Molteni, M., Rosati, R., Aleotti, F., Elmore, U., Lemma, M., Vignali, A., Scabini, S., Casoni Pattacini, G., Luzzi, A., Romairone, E., Marino, F., Lorusso, D., Pezzolla, F., Colombo, F., Baldi, C., Foschi, D., Sampietro, G., Sorrentino, L., Di Saverio, S., Birindelli, A., Segalini, E., Spacca, D., Romano, G. M., Belli, A., Bianco, F., De franciscis, S., Falato, A., Muratore, A., Marsanic, P., Grimaldi, S., Castaldo, N., Ciolli, M. G., Picarella, P., Porfidia, R., Tugnoli, G., Bondurri, A., Cavallo, D., Maffioli, A., Pertusati, A., Pulighe, F., Balestra, F., De Nisco, C., Podda, M., Opocher, E., Longhi, M., Mariani, N. M., Maroni, N., Pisani Ceretti, A., Galleano, R., Aonzo, P., Curletti, G., Reggiani, L., Marconi, M., Del Prete, L., Oldani, M., Pappalardo, R., Zaccone l, S., Scatizzi, M., Baraghini, M., Cantafio, S., Feroci, F., Giani, I., Tutino, R., Cocorullo, G., Gulotta, G., Licari, L., Salamone, G., Sileri, P., Saraceno, F., La Torre, F., Chirletti, P., Coletta, D., De Toma, G., Mingoli, A., Papandrea, M., De Luca, E., Sacco, R., Sammarco, G., Vescio, G., Tonini, V., Bianchini, S., Cervellera, M., Vaccari, S., Cracco, N., Barugola, G., Bertocchi, E., Rossini, R., Ruffo, G., Sartori, A., Clemente, N., De Luca, M., De Luca, A., Scaffidi, G., Lorenzon, L., Balducci, G., Bocchetti, T., Ferri, M., Mercantini, P., Pata, F., Bauce, S., Benevento, A., Bottini, C., Crapa, P. R., Rubbini, M., Anania, G., Carcoforo, P., Cavallesco, G., Feo, C., Yamamoto, T., Sivins, A., Ancans, G., Gerkis, S., Lunis, R., Pcolkins, A., Venskutonis, D., Bradulskis, S., Dainius, E., Subocius, A., Vencius, J., Zeromskas, P., Eismontas, V., Nutautiene, V., Simcikas, D., Tamosiunas, A., Svagzdys, S., Latkauskas, T., Lizdenis, P., Saladzinskas, Z., Tamelis, A., Dulskas, A., Kuliavas, J., Samalavicius, N. E., Poskus, T., Jotautas, V., Mikalauskas, S., Poskus, E., Strupas, K., Zakaria, A. D., Lah, N. N., Wong, M., Zain, W. Z., Zakaria, Z., Mazlan, L., Mohd Azman, Z. A., Sagap, I., Psaila, J., Andrejevic, P., Cini, C., Ellul, S., Pace, K., Ahallat, M., Hamid, M., Hrora, A., Majbar, M. A., Raiss, M., Westerduin, E., Bemelman, W., Buskens, C., Tanis, P., van der Sluis, P. C., Davids, P. H., Pronk, A., Schiphorst, A. H. W., Smakman, N., Zimmerman, D., Koeter, T., Stijns, J., van Loon, Y. -T., Vermaas, M., de Graaf, E., Doornebosch, P., van Hagen, P., van Ruler, O., Toorenvliet, B., Nonner, J., van den Berg, I., van Steensel, L., Vles, W., Melenhorst, J., Orsini, R., Visschers, R., Hoff, C., Blom, R., Marsman, H., Mulder, I., Cense, H., de Castro, S., Demirkiran, A., Hunfeld, M., van Geloven, A., de Groof, J., Hendriks, E., Leeuwenburg, M., van Oorschot, N., Wit, F., Rupert, C., Veldman, P., Keijzers, M., Konsten, J., Den Boer, F., Corver, M., Boerma, E. G., Koolen, L., Martens, M., Van Wijck, K., Ignjatovic, D., Breuer, R., Gurpreet, B., Oresland, T., Tetens Moe, T., Nesbakken, A., Flaaten Backe, I., Wik, T. -A., Radiya, K., Dehli, T., Gjessing, P., Norderval, S., Woll, K., Anwer, M., Qureshi, M. S., Qureshi, A. U., Billah, M., Jawad, M. Y., Raza, A., Urooj, N., Wang, X., Li, L., Jajtner, D., Gasinski, B., Kabiesz, W., Walega, P., Romaniszyn, M., Zawadzki, M., Czarnecki, R., Obuszko, Z., Rzaca, M., Sitarska, M., Silva, P., Duarte, A., Gonçalves, D., Morais, M., Rama, N., Nobre, J., Sales, I., Costa Pereira, J., Costa, S., Costa Pereira, C., Insua, C., Romero, I., Figueiredo, N., Cunha, J., Domingos, H., Vieira, P., Cunha, M., Americano, M., Amorim, E., Rachadell, J., Carvas, J. M., Armas, I., Fernandes, P., Pires, C., Reis, R., Martins, R., Dos Santos, M., Henriques, P., Oliveira, O., Duarte, M., Ferreira, L., Miranda, J., Vilela, N., Corte Real, J., Carlos, S., Frois Borges, M., Moniz Pereira, P., Simões, J., Silva-vaz, P., Bettencourt, V., Gouveia, A., Perez, H., Rainho, R., Bintintan, V., Ciuce, C., Dindelegan, G., Scurtu, R., Seicean, R., Cristian, D., Burcos, T., Grama, F., Mandi, D. M., Richiteanu, G., Miron, A., Calu, V., Enciu, O., Nadragea, M., Parvuletu, R., Mogoanta, S. S., Crafciuc, A., Paitici, S., Negoi, I., Beuran, M., Ciubotaru, C., Prodan, A., Vartic, M., Tomulescu, V., Copaescu, C., Yanishev, A., Abelevich, A., Kokobelyan, A., Lebedeva, M., Luzan, R., Pozdnyakov, A., Cherdancev, D., Mahotin, D., Nesytykh, A., Samsonyuk, V., Pravosudov, I., Ivlev, D., Karachun, A., Lebedev, K., Samsonov, D., Aiupov, R., Feoktistov, D., Garipov, M., Suleymanov, N., Tarasov, N., Rasulov, A., Dzhumabaev, H., Mamedli, Z., Bedzhanyan, A., Popov, D., Sednev, A., Klimenko, A., Semenov, A., Vasilyev, S., Khazov, A., Khanevich, M., Khrykov, G., Katorkin, S., Andreev, P., Chernov, A., Davidova, O., Zhuravlev, A., Achkasov, S., Shakhmatov, D., Shelygin, Y., Sushkov, O., Vardanyan, A., Ilkanich, A., Barbashinov, N., Darvin, V., Onishchenko, S., Voronin, Y., Krivokapić, Z., Barišić, G., Dimitrijević, I., Marković, V., Sekulić, A., Stanojevic, G., Brankovic, B., Nestorovic, M., Pecic, V., Petrovic, D., Kostic, I., Aleksic, A., Dabic, D., Maric, B., Perunicic, V., Radovanovic, Z., Djuric, M., Lukic, D., Radovanovic, D., Cuk, V., Juloski, J., Kenic, M., Krdzic, I., Ngu, J. C., Y. Y., Ng, Teo, N., Korcek, J., Lazorisak, A., Rems, M., Ramovš Trampuš, Å ., Tomazic, A., Grosek, J., Kosir, J., Norcic, G., Vigorita, V., Caceres, N., Casal, E., Ruano, A., Trostchansky, I., Golda, T., Galvez Saldaña, A., Kreisler Moreno, E., Lopez Dominguez, J., Vila Tura, M., Labarga, F., Galvez, P., Maderuelo, V., Suero, C., Bargallo, J., Cayetano, L., Lamas, S., Silva, M. C., Bernal-Sprekelsen, J. C., Gómez, R., Jareño, S., Ríos, A., Vercher, D., García-González, J. -M., Cervera-Aldama, J., Ramos-Prada, J., Santamaría-Olabarrieta, M., Borda, N., Enrriquez-Navascués, J. M., Saralegui, Y., Calero-Lillo, A., Aznar-Puig, S., López-Lara, M. A., Muñoz-Collado, S., Valverde-Sintas, J., Menendez, P., Leon, C., Truan, N., Baldonedo, R., Fernández-Martínez, D., Otero, J., Solar-García, L., Turrado-Rodriguez, V., de Lacy Oliver, F., Lacy Fortuny, A. M., Martin Perez, B., Otero Piñeiro, A. M., Paredes, J., Fernandez, F., Ladra, M. J., Paulos, A., Prieto, D., Beltrán de Heredia, J. P., Blanco Antona, F., de Andrés Asenjo, B., Ferreras García, C., Romero de Diego, A., Cordoba Diaz de Laspra, E., Echazarreta Gallego, E., Elia Guedea, M., Escola, D., Martinez, S., Primo Romaguera, V., Parreño, R., Pastor, L., Rosell, E., Lozoya Trujillo, R., Alós Company, R., Ruiz Carmona, M. D., Solana Bueno, A., Salvans Ruiz, S., Alonso Gonçalves, S., Jiménez- Toscano, M., Pascual Damieta, M., Pera Roman, M., Pellicer-Franco, E. M., Garcia-Marin, J. A., Mengual-Ballester, M., Soria-Aledo, V., Valero-Navarro, G., Vicente-Ruiz, M., Garcia-Zamora, C., Gonzalez-Gil, A., Montoya-Tabares, M. J., Paredes-Quiles, M., Die Trill, J., Abadia, P., Moreno, I., Pina, J. D., Ramos Rubio, D., Escartin, J., Blas, J. L., Fernando, J., Ferrer, R., Garcia Egea, J., Pros, I., Martinez, W., Rius, J., Socías, M., Sabia, D., Castellvi Valls, J., Gonzalez Santin, V., Mompart Garcia, S., Viso Pons, L., Julià, D., Codina-Cazador, A., Farrés, R., Gómez, N., Planellas, P., Cuadrado, M., Camps, I., Rufas, M., Escoll, J., Fermiñán, A., Muriel, P., Sierra, E., Alvarez-Laso, C., Lora, P., Padin, H., Garcia-Septiem, J., Bustamante, C., Jimenez, V., Jimenez-Miramon, J., Ramos, J. L., Gallardo, A. B., Benito, P., Colao, L., Galindo, P., Garcia, C., Forero-Torres, A., Alonso Poza, A., Dieguez Fernandez, B., Gilsanz Martin, C., Hernandez Garcia, M., Rojo López, J. A., Gil López, J. M., González Zunzárren, M., Martínez Alegre, J., Zorrilla Matilla, L. P., Navarro-Sánchez, A., Alcalá Serrano, F. J., López-Fernández, J., Montesdeoca Cabrera, D., Alvarez-Gallego, M., Guevara, J., Pascual Miguelañez, I., Rubio-Perez, I., Gomez Ruiz, M., Alonso Martín, J., Cagigas Fernández, C., Castillo Diego, J., Pando, J. A., Maristany, C., Muñoz-Duyos, A., Rada-Palomino, A., Vargas-Pierola, H., Peña Ros, E., Benavides Buleje, J. A., Muñoz Camarena, J. M., Parra Baños, P. A., Ramirez Faraco, M., Arenal, J. J., Citores, M. A., Marcos, J. L., Sánchez, J., Tinoco, C., García Flórez, L. J., Arias Pacheco, R. D., Mínguez Ruiz, G., Gutiérrez Corral, N., Rodríguez Infante, A., Carrillo López, M. J., Carrasco Prats, M. M., Lage Laredo, A., Martínez Manzano, Á., Rodríguez García, P., Segura-Sampedro, J. J., Alonso-Hernández, N., Fernandez Isart, M., Gamundi Cuesta, M., Ochogavia Segui, A., Ibañez, N., Abrisqueta, J., Lujan, J., Gómez Pérez, R., Corrales Valero, E., Monje Salazar, C., Sanchiz Cardenas, E., Soler Humanes, R., Jimenez-Rodriguez, R. M., De la Portilla, F., Diaz Pavon, J. M., Garcia Cabrera, A. M., Reyes Diaz, M. L., Espin, E., Marinello, F., Martí, M., Sanchez, J. L., Vallribera, F., Orts Mico, F. J., Ortin Navarro, M., Perez Climent, M., Serra Diaz, C., Millan, M., Caro, A., Escuder, J., Espina, B., Feliu, F., Climent Aira, A., Estévez Diz, A., Moreno Asencio, M. T., Varela Mato, A., Vázquez Bouzán, R., Minaya-Bravo, A. M., Diez-Alonso, M. M., Villeta-Plaza, R., Guadalajara, H., Alías, D., García Olmo, D., Pastor, C., Valverde, I., Sanchez Romero, A., Gardea, A., Gil Santos, M., Nimmersgern, T., Serrano Paz, P., Romero-Simó, M., Blasco-Segura, T., Caravaca-García, I., Costa-Navarro, D., Zarco-Pleguezuelos, A., Sánchez-Guillén, L., Flor-Lorente, B., Frasson, M., García-Granero, Á., García-Granero, E., Arencibia, B., Alonso, J., Febles, G., Nogués, E. M., Roque, C., Segelman, J., Nygren, J., Nestler, G., Abraham-Nordling, M., Egenvall, M., Myrelid, P., Jung, B., Loftås, P., Lydrup, M. -L., Azahr, N., Buchwald, P., Mangell, P., Syk, I., Nikberg, M., Carlander, J., Chabok, A., Smedh, K., Tiselius, C., Haapaniemi, S., Benckert, A., Adamina, M., Freil-Lanter, C., Gingert, C., Müller, P., Schäfli, J., Regusci, L., Brenna, M., Fasolini, F., Misteli, H., Kirchhoff, P., Oertli, D., Hahnloser, D., Clerc, D., Hübner, M., Ris, F., Buchs, N. C., Chevallay, M., Morel, P., Schiltz, B., Wang, J. Y., W. -C., Su, Huang, C. -W., C. -J., Ma, Tsai, H. -L., Bugra, D., Agalar, F., Baloglu, H., Basoglu, I., Okkabaz, N., Binboga, E., Biricik, A., Celik, A., Yavuz, E., Canda, A. E., Agalar, C., Fuzun, M., Sokmen, S., Terzi, C., Isik, A., Karip, B., Bilgili, A. C., Leventoğlu, S., Aytac, B., Küçükdiler, E., Yıldız, A., Yuksel, O., Sinan, H., Hancerliogullari, O., Kaymak, S., Kozak, O., Ozer, M. T., Sarici, I. S., Akca, O., Kalayci, M. U., Kara, Y., Agcaoglu, O., Balik, E., Bayram, O., Özbalcı, G. S., Özkan, B. B., Karabacak, U., Sungurtekin, U., Ozgen, U., Demirbas, S., Öztürk, E., Isik, O., Yilmazlar, T., Colak, E., Karagul, S., Kinas, V., Fearnhead, N., Lord, I., Stewart, P., Zammit, M., Arnold, S., Battersby, N. J., Broadhurst, J., Moran, S., Seretis, F., Shabbir, J., Jones, C., Kynaston, J., Vimalachandran, D., Blower, E., Mcfaul, C., Mcwhirter, D., Pilkington, J., Wilson, T., Chowdhary, M., Stubbs, B., Abdalkoddus, M., Lai, C., Thavanesan, N., Yao, C., Agarwal, T., Dindyal, S., Hill, R. M. C., Reade, S., Slesser, A., Paterson, H., Balfour, A., Boland, M., Geraghty, A., O'Kelly, J., Patel, P., Tezas, S., Yahia, S., Jadhav, V., Marimuthu, K., Narayanan, A., Piramanayagam, B., Bradley, N., Buchanan, F., Paul, K., Singh, J., Thomson, K., Korsgen, S., Bedford, M., Lee, K., Leong, K., Mcarthur, D., Bhangu, A., Malik, S., Mohamed, I., Cunha, P., Pilavas, A., Reddy, A., Ahmed, S., Ahmed, A., Voll, J., Velchuru, V., Lal, R., Mirshekar-Syahkal, B., Kassai, M., Aleem, M., Keogh-Bootland, S., Sarmah, P., Brown, S., Keegan, R., Kelkar, A., Sen, P., Oliveira-Cunha, M., Chaudhri, S., Fares, R., Singh, B., Thomas, W. M., Aslam, M. I., Boyle, K., Hemingway, D., Miller, A., Norwood, M., Gurjar, S., Al-Saeedi, M., Anandan, L., Sudlow, A., Zampitis, N., Malik, K., Bogdan, M., Smart, C., Iqbal, M. R., Bailey, S., Lawes, D., Omar, G., Tamhane, R., Evans, M., Ather, S., Lim, J., Nageswaran, H., Taylor, G., Hunt, L., Nicholls, J., Shaikh, I., Muscara, F., O'Brien, J., Photi, E., Stearns, A., Meylemans, D., Cunningham, C., Hompes, R., Tennakoon, A., Kumarasinghe, N., Rao, M., Upanishad, I., Khan, J., Ahmad, N., Shweejawee, Z., Stefan, S., Smart, N., Daniels, I., Gregoir, T., Longstaff, L., Mcdermott, F., Varcada, M., Drami, I., Gala, T., Moggia, E., Ratnatunga, K., Harries, R., Hayes, J., Williams, G., Raymond, T., Bronder, C., Davies, E., Hawkin, P., Ryska, O., Ayral, K., Beveridge, A., Bhowmik, A., Gill, M., Simpson, R., Schofield, A., Mcardle, K., Parmar, M., Williamson, M., Burton, H., Courtney, E., Grant, C., Saracino, A., Newton, K., Epstein, J., Branagan, G., Bignell, M., Symankewicz, M., Zaman, S., Mankotia, R., Siddiqui, Z., Torrance, A., Artioukh, D., Eggleston, M., Gokul, K., Selwyn, D., Warusavitarne, J., Chandrasinghe, P., Grainger, J., Leo, C. A., Vaizey, C. J., Harris, G., Levy, B., Skull, A., Thaha, M., Garg, A., Patel, H., Ramsanahie, A., Mondragon-Pritchard, M., Cuinas Leon, K., Shukla, A., Brewer, H., Fitzgerald, J., Kho, H., Torkington, J., Tate, S., Wheat, J., Smolarek, S., Platt, E., Rossi, B., Tham, J. C., Knight, J., Richardson, J., Tzivanakis, A., Gregori, M., Ashraf, M. A., Atif, M., Santos, J., Saffaf, N., Canning, L., Chandratreya, N., Bowen, M., Graham, B., Hamad, Y., Kaubrys, M., Chaudhry, Z. U., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Gouvas, N., Nicol, D., Pandey, S., Zilvetti, M., Sharma, A., Fatayer, T., Mothe, S., Rahman, M., Curtis, N., Allison, A., Dalton, R., Francis, N., Ockrim, J., Psaras, G., Dudarovaska, H., Marharint, T., Mostovoy, E., Voloshin, S., Kolesnik, O., Makhmudov, D., Altinel, Y., Iqbal, A., Cunningham, L., Go, K., Tan, S.
Přispěvatelé: European Society of Coloproctology (ESCP) Cohort Studies, Tonini V, Cervellera M, Vaccari S, Battersby, Nick, Glasbey, James C., Neary, Peter, Negoi, Ionut, Kamarajah, Sivesh, Sgro, Alessandro, Bhangu, Aneel, Pinkney, Thoma, Frasson, Matteo, El-Hussuna, Alaa, Battersby, Nick J., Buchs, Nicolas C., Buskens, Christianne, Chaudri, Sanjay, Gallo, Gaetano, Glasbey, Jame, Minaya-Bravo, Ana María, Morton, Dion, Nepogodiev, Dmitri, Pata, Francesco, Sánchez-Guillén, Lui, Singh, Baljit, Zmora, Oded, Perry, Rita, Magill, Laura, Altomare, Donato, Bemelman, Willem, Brown, Steven, Denost, Quentin, Knowles, Charle, Laurberg, Søren, Lefevre, Jérémie H., Möeslein, Gabriela, Pinkney, Tom, Vaizey, Carolynne, Bilali, S., Bilali, V., Salomon, M., Cillo, M., Estefania, D., Patron Uriburu, J., Ruiz, H., Farina, P., Carballo, F., Guckenheimer, S., Proud, D., Brouwer, R., Bui, A., Nguyen, B., Smart, P., Warwick, A., Theodore, J. E., Herbst, F., Birsan, T., Dauser, B., Ghaffari, S., Hartig, N., Stift, A., Argeny, S., Unger, L., Strouhal, R., Heuberger, A., Varabei, A., Lahodzich, N., Makhmudov, A., Selniahina, L., Feryn, T., Leupe, T., Maes, L., Reynvoet, E., Van Langenhove, K., Nachtergaele, M., Monami, B., Francart, D., Jehaes, C., Markiewicz, S., Weerts, J., Van Belle, K., Bomans, B., Cavenaile, V., Nijs, Y., Vertruyen, M., Pletinckx, P., Claeys, D., Defoort, B., Muysoms, F., Van Cleven, S., Lange, C., Vindevoghel, K., Wolthuis, A., Todorovic, M., Dabic, S., Kenjic, B., Lovric, S., Vidovic, J., Delibegovic, S., Mehmedovic, Z., Christiano, A., Lombardi, B., Marchiori, M., Tercioti, V., Dardanov, D., Petkov, P., Simonova, L., Yonkov, A., Zhivkov, E., Maslyankov, S., Pavlov, V., Sokolov, M., Todorov, G., Stoyanov, V., Batashki, I., Iarumov, N., Lozev, I., Moshev, B., Slavchev, M., Atanasov, B., Belev, N., Krstev, P., Penkov, R., Šantak, G., Ćosić, J., Previšić, A., Vukušić, L., Zukanović, G., Zelić, M., Kršul, D., Lekić Vitlov, V., Mendrila, D., Orhalmi, J., Dusek, T., Maly, O., Paral, J., Sotona, O., Skrovina, M., Bencurik, V., Machackova, M., Kala, Z., Farkašová, M., Grolich, T., Procházka, V., Hoch, J., Kocian, P., Martinek, L., Antos, F., Pruchova, V., El-Hussuna, A., Ceccotti, A., Madsbøll, T., Straarup, D., Uth Ovesen, A., Christensen, P., Bondeven, P., Edling, P., Elfeki, H., Alexandrovich Gameza, V., Michelsen Bach, S., Zheltiakova, I., Krarup, P. M., Krogh, A., Rolff, H. -C., Lykke, J., Juvik, A. F., Lóven, H. H. K., Marckmann, M., Osterkamp, J. T. F., Madsen, A. H., Worsøe, J., Ugianskis, A., Kjær, M. D., Youn Cho Lee, B., Khalid, A., Kristensen, M. H., El Sorogy, M., Elgeidie, A., Elhemaly, M., El Nakeeb, A., Elrefai, M., Shalaby, M., Emile, S., Omar, W., Sakr, A., Thabet, W., Awny, S., Metwally, I., Refky, B., Shams, N., Zuhdy, M., Lepistö, A., Keränen, I., Kivelä, A., Lehtonen, T., Siironen, P., Rautio, T., Ahonen-Siirtola, M., Klintrup, K., Paarnio, K., Takala, H., Hyöty, M., Haukijärvi, E., Kotaluoto, S. -M., Lehto, K., Tomminen, T., Huhtinen, H., Carpelan, A., Karvonen, J., Rantala, A., Varpe, P., Cotte, E., Francois, Y., Glehen, O., Passot, G., D'Alessandro, A., Chouillard, E., Etienne, J. C., Ghilles, E., Vinson-Bonnet, B., Germain, A., Ayav, A., Bresler, L., Chevalier, R., Denost, Q., Didailler, R., Rullier, E., Tiret, E., Chafai, N., Lefevre, J. H., Parc, Y., Sielezneff, I., Mege, D., Lakkis, Z., Barussaud, M., Krones, C., Bock, B., Webler, R., Baral, J., Lang, T., Münch, S., Pullig, F., Schön, M., Hinz, S., Becker, T., Möller, T., Richter, F., Schafmayer, C., Hardt, J., Kienle, P., Crescenti, F., Ahmad, M., Soleiman, Y., Papaconstantinou, I., Gklavas, A., Nastos, K., Theodosopoulos, T., Vezakis, A., Stamou, K., Saridaki, A., Xynos, E., Paraskakis, S., Zervakis, N., Skroubis, G., Amanatidis, T., Germanos, S., Maroulis, I., Papadopoulos, G., Dimitriou, N., Alexandrou, A., Felekouras, E., Griniatsos, J., Karavokyros, I., Papadopoulos, A., Chouliaras, C., Ioannidis, P., Katsounis, D., Kefalou, E., Katsoulis, I. E., Balalis, D., Korkolis, D. P., Manatakis, D., Tzovaras, G., Baloyiannis, I., Mamaloudis, I., Lázár, G., Ábraham, S., Paszt, A., Simonka, Z., Tóth, I., Zaránd, A., Baranyai, Z., Ferreira, G., Harsányi, L., Ónody, P., Banky, B., Burány, Ã ., Lakatos, M., Marton, J., Solymosi, A., Besznyák, I., Bursics, A., Papp, G., Saftics, G., Svastics, I., Valsdottir, E., Atladottir, J., Jonsson, T., Moller, P., Sigurdsson, H., Gupta, S. K., Gupta, S., Kaul, N., Mohan, S., Sharma, G., Wani, R., Chowdri, N., Khan, M., Mehraj, A., Parray, F. Q., Coveney, A., Burke, J., Deasy, J., El-Masry, S., Mcnamara, D., Khan, M. F., Cahill, R., Faul, E., Mulsow, J., Shields, C., Kelly, M. E., Bass, G., Martin, S. T., O'Connell, R., Ryan, E., Connelly, T., Ahmad, G., Bukhari, W., Cooke, F., Zmora, O., Gold Deutch, R., Haim, N., Lavy, R., Moscovici, A., Shussman, N., Gefen, R., Marom, G., Pikarsky, A., Weiss, D., Avital, S., Hermann, N., Raguan, B., Slavin, M., White, I., Wasserberg, N., Arieli, H., Gurevich, N., Freund, M. R., Dorot, S., Edden, Y., Halfteck, G., Reissman, P., Pery, R., Tulchinsky, H., Weizman, A., Agresta, F., Curinga, R., Finotti, E., Savino, G., Verza, L. A., Asteria, C. R., Boccia, L., Pascariello, A., Tamini, N., Bugatti, A., Gianotti, L., Totis, M., Vincenti, L., Andriola, V., Giannini, I., Travaglio, E., Balestri, R., Buccianti, P., Roffi, N., Rossi, E., Urbani, L., Mellano, A., Cinquegrana, A., Lauretta, A., Belluco, C., Mistrangelo, M., Allaix, M. E., Arolfo, S., Morino, M., Testa, V., Delrio, P., Pace, U., Rega, D., Scala, D., Gallo, G., Clerico, G., Cornaglia, S., Realis Luc, A., Trompetto, M., Ugolini, G., Antonacci, N., Fabbri, S., Montroni, I., Zattoni, D., D'Urbano, C., Cornelli, A., Viti, M., Inama, M., Bacchion, M., Casaril, A., Impellizzeri, H., Moretto, G., Spinelli, A., Carvello, M., David, G., Di Candido, F., Sacchi, M., Frontali, A., Ceriani, V., Molteni, M., Rosati, R., Aleotti, F., Elmore, U., Lemma, M., Vignali, A., Scabini, S., Casoni Pattacini, G., Luzzi, A., Romairone, E., Marino, F., Lorusso, D., Pezzolla, F., Colombo, F., Baldi, C., Foschi, D., Sampietro, G., Sorrentino, L., Di Saverio, S., Birindelli, A., Segalini, E., Spacca, D., Romano, G. M., Belli, A., Bianco, F., De franciscis, S., Falato, A., Muratore, A., Marsanic, P., Grimaldi, S., Castaldo, N., Ciolli, M. G., Picarella, P., Porfidia, R., Tugnoli, G., Bondurri, A., Cavallo, D., Maffioli, A., Pertusati, A., Pulighe, F., Balestra, F., De Nisco, C., Podda, M., Opocher, E., Longhi, M., Mariani, N. M., Maroni, N., Pisani Ceretti, A., Galleano, R., Aonzo, P., Curletti, G., Reggiani, L., Marconi, M., Del Prete, L., Oldani, M., Pappalardo, R., Zaccone l, S., Scatizzi, M., Baraghini, M., Cantafio, S., Feroci, F., Giani, I., Tutino, R., Cocorullo, G., Gulotta, G., Licari, L., Salamone, G., Sileri, P., Saraceno, F., La Torre, F., Chirletti, P., Coletta, D., De Toma, G., Mingoli, A., Papandrea, M., De Luca, E., Sacco, R., Sammarco, G., Vescio, G., Tonini, V., Bianchini, S., Cervellera, M., Vaccari, S., Cracco, N., Barugola, G., Bertocchi, E., Rossini, R., Ruffo, G., Sartori, A., Clemente, N., De Luca, M., De Luca, A., Scaffidi, G., Lorenzon, L., Balducci, G., Bocchetti, T., Ferri, M., Mercantini, P., Pata, F., Bauce, S., Benevento, A., Bottini, C., Crapa, P. R., Rubbini, M., Anania, G., Carcoforo, P., Cavallesco, G., Feo, C., Yamamoto, T., Sivins, A., Ancans, G., Gerkis, S., Lunis, R., Pcolkins, A., Venskutonis, D., Bradulskis, S., Dainius, E., Subocius, A., Vencius, J., Zeromskas, P., Eismontas, V., Nutautiene, V., Simcikas, D., Tamosiunas, A., Svagzdys, S., Latkauskas, T., Lizdenis, P., Saladzinskas, Z., Tamelis, A., Dulskas, A., Kuliavas, J., Samalavicius, N. E., Poskus, T., Jotautas, V., Mikalauskas, S., Poskus, E., Strupas, K., Zakaria, A. D., Lah, N. N., Wong, M., Zain, W. Z., Zakaria, Z., Mazlan, L., Mohd Azman, Z. A., Sagap, I., Psaila, J., Andrejevic, P., Cini, C., Ellul, S., Pace, K., Ahallat, M., Hamid, M., Hrora, A., Majbar, M. A., Raiss, M., Westerduin, E., Bemelman, W., Buskens, C., Tanis, P., van der Sluis, P. C., Davids, P. H., Pronk, A., Schiphorst, A. H. W., Smakman, N., Zimmerman, D., Koeter, T., Stijns, J., van Loon, Y. -T., Vermaas, M., de Graaf, E., Doornebosch, P., van Hagen, P., van Ruler, O., Toorenvliet, B., Nonner, J., van den Berg, I., van Steensel, L., Vles, W., Melenhorst, J., Orsini, R., Visschers, R., Hoff, C., Blom, R., Marsman, H., Mulder, I., Cense, H., de Castro, S., Demirkiran, A., Hunfeld, M., van Geloven, A., de Groof, J., Hendriks, E., Leeuwenburg, M., van Oorschot, N., Wit, F., Rupert, C., Veldman, P., Keijzers, M., Konsten, J., Den Boer, F., Corver, M., Boerma, E. G., Koolen, L., Martens, M., Van Wijck, K., Ignjatovic, D., Breuer, R., Gurpreet, B., Oresland, T., Tetens Moe, T., Nesbakken, A., Flaaten Backe, I., Wik, T. -A., Radiya, K., Dehli, T., Gjessing, P., Norderval, S., Woll, K., Anwer, M., Qureshi, M. S., Qureshi, A. U., Billah, M., Jawad, M. Y., Raza, A., Urooj, N., Wang, X., Li, L., Jajtner, D., Gasinski, B., Kabiesz, W., Walega, P., Romaniszyn, M., Zawadzki, M., Czarnecki, R., Obuszko, Z., Rzaca, M., Sitarska, M., Silva, P., Duarte, A., Gonçalves, D., Morais, M., Rama, N., Nobre, J., Sales, I., Costa Pereira, J., Costa, S., Costa Pereira, C., Insua, C., Romero, I., Figueiredo, N., Cunha, J., Domingos, H., Vieira, P., Cunha, M., Americano, M., Amorim, E., Rachadell, J., Carvas, J. M., Armas, I., Fernandes, P., Pires, C., Reis, R., Martins, R., Dos Santos, M., Henriques, P., Oliveira, O., Duarte, M., Ferreira, L., Miranda, J., Vilela, N., Corte Real, J., Carlos, S., Frois Borges, M., Moniz Pereira, P., Simões, J., Silva-vaz, P., Bettencourt, V., Gouveia, A., Perez, H., Rainho, R., Bintintan, V., Ciuce, C., Dindelegan, G., Scurtu, R., Seicean, R., Cristian, D., Burcos, T., Grama, F., Mandi, D. M., Richiteanu, G., Miron, A., Calu, V., Enciu, O., Nadragea, M., Parvuletu, R., Mogoanta, S. S., Crafciuc, A., Paitici, S., Negoi, I., Beuran, M., Ciubotaru, C., Prodan, A., Vartic, M., Tomulescu, V., Copaescu, C., Yanishev, A., Abelevich, A., Kokobelyan, A., Lebedeva, M., Luzan, R., Pozdnyakov, A., Cherdancev, D., Mahotin, D., Nesytykh, A., Samsonyuk, V., Pravosudov, I., Ivlev, D., Karachun, A., Lebedev, K., Samsonov, D., Aiupov, R., Feoktistov, D., Garipov, M., Suleymanov, N., Tarasov, N., Rasulov, A., Dzhumabaev, H., Mamedli, Z., Bedzhanyan, A., Popov, D., Sednev, A., Klimenko, A., Semenov, A., Vasilyev, S., Khazov, A., Khanevich, M., Khrykov, G., Katorkin, S., Andreev, P., Chernov, A., Davidova, O., Zhuravlev, A., Achkasov, S., Shakhmatov, D., Shelygin, Y., Sushkov, O., Vardanyan, A., Ilkanich, A., Barbashinov, N., Darvin, V., Onishchenko, S., Voronin, Y., Krivokapić, Z., Barišić, G., Dimitrijević, I., Marković, V., Sekulić, A., Stanojevic, G., Brankovic, B., Nestorovic, M., Pecic, V., Petrovic, D., Kostic, I., Aleksic, A., Dabic, D., Maric, B., Perunicic, V., Radovanovic, Z., Djuric, M., Lukic, D., Radovanovic, D., Cuk, V., Juloski, J., Kenic, M., Krdzic, I., Ngu, J. C., Ng, Y. Y., Teo, N., Korcek, J., Lazorisak, A., Rems, M., Ramovš Trampuš, Å , Tomazic, A., Grosek, J., Kosir, J., Norcic, G., Vigorita, V., Caceres, N., Casal, E., Ruano, A., Trostchansky, I., Golda, T., Galvez Saldaña, A., Kreisler Moreno, E., Lopez Dominguez, J., Vila Tura, M., Labarga, F., Galvez, P., Maderuelo, V., Suero, C., Bargallo, J., Cayetano, L., Lamas, S., Silva, M. C., Bernal-Sprekelsen, J. C., Gómez, R., Jareño, S., Ríos, A., Vercher, D., García-González, J. -M., Cervera-Aldama, J., Ramos-Prada, J., Santamaría-Olabarrieta, M., Borda, N., Enrriquez-Navascués, J. M., Saralegui, Y., Calero-Lillo, A., Aznar-Puig, S., López-Lara, M. A., Muñoz-Collado, S., Valverde-Sintas, J., Menendez, P., Leon, C., Truan, N., Baldonedo, R., Fernández-Martínez, D., Otero, J., Solar-García, L., Turrado-Rodriguez, V., de Lacy Oliver, F., Lacy Fortuny, A. M., Martin Perez, B., Otero Piñeiro, A. M., Paredes, J., Fernandez, F., Ladra, M. J., Paulos, A., Prieto, D., Beltrán de Heredia, J. P., Blanco Antona, F., de Andrés Asenjo, B., Ferreras García, C., Romero de Diego, A., Cordoba Diaz de Laspra, E., Echazarreta Gallego, E., Elia Guedea, M., Escola, D., Martinez, S., Primo Romaguera, V., Parreño, R., Pastor, L., Rosell, E., Lozoya Trujillo, R., Alós Company, R., Ruiz Carmona, M. D., Solana Bueno, A., Salvans Ruiz, S., Alonso Gonçalves, S., Jiménez- Toscano, M., Pascual Damieta, M., Pera Roman, M., Pellicer-Franco, E. M., Garcia-Marin, J. A., Mengual-Ballester, M., Soria-Aledo, V., Valero-Navarro, G., Vicente-Ruiz, M., Garcia-Zamora, C., Gonzalez-Gil, A., Montoya-Tabares, M. J., Paredes-Quiles, M., Die Trill, J., Abadia, P., Moreno, I., Pina, J. D., Ramos Rubio, D., Escartin, J., Blas, J. L., Fernando, J., Ferrer, R., Garcia Egea, J., Pros, I., Martinez, W., Rius, J., Socías, M., Sabia, D., Castellvi Valls, J., Gonzalez Santin, V., Mompart Garcia, S., Viso Pons, L., Julià, D., Codina-Cazador, A., Farrés, R., Gómez, N., Planellas, P., Cuadrado, M., Camps, I., Rufas, M., Escoll, J., Fermiñán, A., Muriel, P., Sierra, E., Alvarez-Laso, C., Lora, P., Padin, H., Garcia-Septiem, J., Bustamante, C., Jimenez, V., Jimenez-Miramon, J., Ramos, J. L., Gallardo, A. B., Benito, P., Colao, L., Galindo, P., Garcia, C., Forero-Torres, A., Alonso Poza, A., Dieguez Fernandez, B., Gilsanz Martin, C., Hernandez Garcia, M., Rojo López, J. A., Gil López, J. M., González Zunzárren, M., Martínez Alegre, J., Zorrilla Matilla, L. P., Navarro-Sánchez, A., Alcalá Serrano, F. J., López-Fernández, J., Montesdeoca Cabrera, D., Alvarez-Gallego, M., Guevara, J., Pascual Miguelañez, I., Rubio-Perez, I., Gomez Ruiz, M., Alonso Martín, J., Cagigas Fernández, C., Castillo Diego, J., Pando, J. A., Maristany, C., Muñoz-Duyos, A., Rada-Palomino, A., Vargas-Pierola, H., Peña Ros, E., Benavides Buleje, J. A., Muñoz Camarena, J. M., Parra Baños, P. A., Ramirez Faraco, M., Arenal, J. J., Citores, M. A., Marcos, J. L., Sánchez, J., Tinoco, C., García Flórez, L. J., Arias Pacheco, R. D., Mínguez Ruiz, G., Gutiérrez Corral, N., Rodríguez Infante, A., Carrillo López, M. J., Carrasco Prats, M. M., Lage Laredo, A., Martínez Manzano, Ã ., Rodríguez García, P., Segura-Sampedro, J. J., Alonso-Hernández, N., Fernandez Isart, M., Gamundi Cuesta, M., Ochogavia Segui, A., Ibañez, N., Abrisqueta, J., Lujan, J., Gómez Pérez, R., Corrales Valero, E., Monje Salazar, C., Sanchiz Cardenas, E., Soler Humanes, R., Jimenez-Rodriguez, R. M., De la Portilla, F., Diaz Pavon, J. M., Garcia Cabrera, A. M., Reyes Diaz, M. L., Espin, E., Marinello, F., Martí, M., Sanchez, J. L., Vallribera, F., Orts Mico, F. J., Ortin Navarro, M., Perez Climent, M., Serra Diaz, C., Millan, M., Caro, A., Escuder, J., Espina, B., Feliu, F., Climent Aira, A., Estévez Diz, A., Moreno Asencio, M. T., Varela Mato, A., Vázquez Bouzán, R., Minaya-Bravo, A. M., Diez-Alonso, M. M., Villeta-Plaza, R., Guadalajara, H., Alías, D., García Olmo, D., Pastor, C., Valverde, I., Sanchez Romero, A., Gardea, A., Gil Santos, M., Nimmersgern, T., Serrano Paz, P., Romero-Simó, M., Blasco-Segura, T., Caravaca-García, I., Costa-Navarro, D., Zarco-Pleguezuelos, A., Sánchez-Guillén, L., Flor-Lorente, B., Frasson, M., García-Granero, Ã ., García-Granero, E., Arencibia, B., Alonso, J., Febles, G., Nogués, E. M., Roque, C., Segelman, J., Nygren, J., Nestler, G., Abraham-Nordling, M., Egenvall, M., Myrelid, P., Jung, B., Loftås, P., Lydrup, M. -L., Azahr, N., Buchwald, P., Mangell, P., Syk, I., Nikberg, M., Carlander, J., Chabok, A., Smedh, K., Tiselius, C., Haapaniemi, S., Benckert, A., Adamina, M., Freil-Lanter, C., Gingert, C., Müller, P., Schäfli, J., Regusci, L., Brenna, M., Fasolini, F., Misteli, H., Kirchhoff, P., Oertli, D., Hahnloser, D., Clerc, D., Hübner, M., Ris, F., Buchs, N. C., Chevallay, M., Morel, P., Schiltz, B., Wang, J. Y., Su, W. -C., Huang, C. -W., Ma, C. -J., Tsai, H. -L., Bugra, D., Agalar, F., Baloglu, H., Basoglu, I., Okkabaz, N., Binboga, E., Biricik, A., Celik, A., Yavuz, E., Canda, A. E., Agalar, C., Fuzun, M., Sokmen, S., Terzi, C., Isik, A., Karip, B., Bilgili, A. C., Leventoğlu, S., Aytac, B., Küçükdiler, E., Yıldız, A., Yuksel, O., Sinan, H., Hancerliogullari, O., Kaymak, S., Kozak, O., Ozer, M. T., Sarici, I. S., Akca, O., Kalayci, M. U., Kara, Y., Agcaoglu, O., Balik, E., Bayram, O., Özbalcı, G. S., Özkan, B. B., Karabacak, U., Sungurtekin, U., Ozgen, U., Demirbas, S., Öztürk, E., Isik, O., Yilmazlar, T., Colak, E., Karagul, S., Kinas, V., Fearnhead, N., Lord, I., Stewart, P., Zammit, M., Arnold, S., Battersby, N. J., Broadhurst, J., Moran, S., Seretis, F., Shabbir, J., Jones, C., Kynaston, J., Vimalachandran, D., Blower, E., Mcfaul, C., Mcwhirter, D., Pilkington, J., Wilson, T., Chowdhary, M., Stubbs, B., Abdalkoddus, M., Lai, C., Thavanesan, N., Yao, C., Agarwal, T., Dindyal, S., Hill, R. M. C., Reade, S., Slesser, A., Paterson, H., Balfour, A., Boland, M., Geraghty, A., O'Kelly, J., Patel, P., Tezas, S., Yahia, S., Jadhav, V., Marimuthu, K., Narayanan, A., Piramanayagam, B., Bradley, N., Buchanan, F., Paul, K., Singh, J., Thomson, K., Korsgen, S., Bedford, M., Lee, K., Leong, K., Mcarthur, D., Bhangu, A., Malik, S., Mohamed, I., Cunha, P., Pilavas, A., Reddy, A., Ahmed, S., Ahmed, A., Voll, J., Velchuru, V., Lal, R., Mirshekar-Syahkal, B., Kassai, M., Aleem, M., Keogh-Bootland, S., Sarmah, P., Brown, S., Keegan, R., Kelkar, A., Sen, P., Oliveira-Cunha, M., Chaudhri, S., Fares, R., Singh, B., Thomas, W. M., Aslam, M. I., Boyle, K., Hemingway, D., Miller, A., Norwood, M., Gurjar, S., Al-Saeedi, M., Anandan, L., Sudlow, A., Zampitis, N., Malik, K., Bogdan, M., Smart, C., Iqbal, M. R., Bailey, S., Lawes, D., Omar, G., Tamhane, R., Evans, M., Ather, S., Lim, J., Nageswaran, H., Taylor, G., Hunt, L., Nicholls, J., Shaikh, I., Muscara, F., O'Brien, J., Photi, E., Stearns, A., Meylemans, D., Cunningham, C., Hompes, R., Tennakoon, A., Kumarasinghe, N., Rao, M., Upanishad, I., Khan, J., Ahmad, N., Shweejawee, Z., Stefan, S., Smart, N., Daniels, I., Gregoir, T., Longstaff, L., Mcdermott, F., Varcada, M., Drami, I., Gala, T., Moggia, E., Ratnatunga, K., Harries, R., Hayes, J., Williams, G., Raymond, T., Bronder, C., Davies, E., Hawkin, P., Ryska, O., Ayral, K., Beveridge, A., Bhowmik, A., Gill, M., Simpson, R., Schofield, A., Mcardle, K., Parmar, M., Williamson, M., Burton, H., Courtney, E., Grant, C., Saracino, A., Newton, K., Epstein, J., Branagan, G., Bignell, M., Symankewicz, M., Zaman, S., Mankotia, R., Siddiqui, Z., Torrance, A., Artioukh, D., Eggleston, M., Gokul, K., Selwyn, D., Warusavitarne, J., Chandrasinghe, P., Grainger, J., Leo, C. A., Vaizey, C. J., Harris, G., Levy, B., Skull, A., Thaha, M., Garg, A., Patel, H., Ramsanahie, A., Mondragon-Pritchard, M., Cuinas Leon, K., Shukla, A., Brewer, H., Fitzgerald, J., Kho, H., Torkington, J., Tate, S., Wheat, J., Smolarek, S., Platt, E., Rossi, B., Tham, J. C., Knight, J., Richardson, J., Tzivanakis, A., Gregori, M., Ashraf, M. A., Atif, M., Santos, J., Saffaf, N., Canning, L., Chandratreya, N., Bowen, M., Graham, B., Hamad, Y., Kaubrys, M., Chaudhry, Z. U., Bhan, C., Mukhtar, H., Oshowo, A., Wilson, J., Gouvas, N., Nicol, D., Pandey, S., Zilvetti, M., Sharma, A., Fatayer, T., Mothe, S., Rahman, M., Curtis, N., Allison, A., Dalton, R., Francis, N., Ockrim, J., Psaras, G., Dudarovaska, H., Marharint, T., Mostovoy, E., Voloshin, S., Kolesnik, O., Makhmudov, D., Altinel, Y., Iqbal, A., Cunningham, L., Go, K., Tan, S., Surgery, Battersby, N, Glasbey, J, Neary, P, Negoi, I, Kamarajah, S, Sgro, A, Bhangu, A, Pinkney, T, Frasson, M, El-Hussuna, A, Buchs, N, Buskens, C, Chaudri, S, Gallo, G, Minaya-Bravo, A, Morton, D, Nepogodiev, D, Pata, F, Sanchez-Guillen, L, Singh, B, Zmora, O, Perry, R, Magill, L, Altomare, D, Bemelman, W, Brown, S, Denost, Q, Knowles, C, Laurberg, S, Lefevre, J, Moeslein, G, Vaizey, C, Bilali, S, Bilali, V, Salomon, M, Cillo, M, Estefania, D, Patron Uriburu, J, Ruiz, H, Farina, P, Carballo, F, Guckenheimer, S, Proud, D, Brouwer, R, Bui, A, Nguyen, B, Smart, P, Warwick, A, Theodore, J, Herbst, F, Birsan, T, Dauser, B, Ghaffari, S, Hartig, N, Stift, A, Argeny, S, Unger, L, Strouhal, R, Heuberger, A, Varabei, A, Lahodzich, N, Makhmudov, A, Selniahina, L, Feryn, T, Leupe, T, Maes, L, Reynvoet, E, Van Langenhove, K, Nachtergaele, M, Monami, B, Francart, D, Jehaes, C, Markiewicz, S, Weerts, J, Van Belle, K, Bomans, B, Cavenaile, V, Nijs, Y, Vertruyen, M, Pletinckx, P, Claeys, D, Defoort, B, Muysoms, F, Van Cleven, S, Lange, C, Vindevoghel, K, Wolthuis, A, Todorovic, M, Dabic, S, Kenjic, B, Lovric, S, Vidovic, J, Delibegovic, S, Mehmedovic, Z, Christiano, A, Lombardi, B, Marchiori, M, Tercioti, V, Dardanov, D, Petkov, P, Simonova, L, Yonkov, A, Zhivkov, E, Maslyankov, S, Pavlov, V, Sokolov, M, Todorov, G, Stoyanov, V, Batashki, I, Iarumov, N, Lozev, I, Moshev, B, Slavchev, M, Atanasov, B, Belev, N, Krstev, P, Penkov, R, Santak, G, Cosic, J, Previsic, A, Vukusic, L, Zukanovic, G, Zelic, M, Krsul, D, Lekic Vitlov, V, Mendrila, D, Orhalmi, J, Dusek, T, Maly, O, Paral, J, Sotona, O, Skrovina, M, Bencurik, V, Machackova, M, Kala, Z, Farkasova, M, Grolich, T, Prochazka, V, Hoch, J, Kocian, P, Martinek, L, Antos, F, Pruchova, V, Ceccotti, A, Madsboll, T, Straarup, D, Uth Ovesen, A, Christensen, P, Bondeven, P, Edling, P, Elfeki, H, Alexandrovich Gameza, V, Michelsen Bach, S, Zheltiakova, I, Krarup, P, Krogh, A, Rolff, H, Lykke, J, Juvik, A, Loven, H, Marckmann, M, Osterkamp, J, Madsen, A, Worsoe, J, Ugianskis, A, Kjaer, M, Youn Cho Lee, B, Khalid, A, Kristensen, M, El Sorogy, M, Elgeidie, A, Elhemaly, M, El Nakeeb, A, Elrefai, M, Shalaby, M, Emile, S, Omar, W, Sakr, A, Thabet, W, Awny, S, Metwally, I, Refky, B, Shams, N, Zuhdy, M, Lepisto, A, Keranen, I, Kivela, A, Lehtonen, T, Siironen, P, Rautio, T, Ahonen-Siirtola, M, Klintrup, K, Paarnio, K, Takala, H, Hyoty, M, Haukijarvi, E, Kotaluoto, S, Lehto, K, Tomminen, T, Huhtinen, H, Carpelan, A, Karvonen, J, Rantala, A, Varpe, P, Cotte, E, Francois, Y, Glehen, O, Passot, G, D'Alessandro, A, Chouillard, E, Etienne, J, Ghilles, E, Vinson-Bonnet, B, Germain, A, Ayav, A, Bresler, L, Chevalier, R, Didailler, R, Rullier, E, Tiret, E, Chafai, N, Parc, Y, Sielezneff, I, Mege, D, Lakkis, Z, Barussaud, M, Krones, C, Bock, B, Webler, R, Baral, J, Lang, T, Munch, S, Pullig, F, Schon, M, Hinz, S, Becker, T, Moller, T, Richter, F, Schafmayer, C, Hardt, J, Kienle, P, Crescenti, F, Ahmad, M, Soleiman, Y, Papaconstantinou, I, Gklavas, A, Nastos, K, Theodosopoulos, T, Vezakis, A, Stamou, K, Saridaki, A, Xynos, E, Paraskakis, S, Zervakis, N, Skroubis, G, Amanatidis, T, Germanos, S, Maroulis, I, Papadopoulos, G, Dimitriou, N, Alexandrou, A, Felekouras, E, Griniatsos, J, Karavokyros, I, Papadopoulos, A, Chouliaras, C, Ioannidis, P, Katsounis, D, Kefalou, E, Katsoulis, I, Balalis, D, Korkolis, D, Manatakis, D, Tzovaras, G, Baloyiannis, I, Mamaloudis, I, Lazar, G, Abraham, S, Paszt, A, Simonka, Z, Toth, I, Zarand, A, Baranyai, Z, Ferreira, G, Harsanyi, L, Onody, P, Banky, B, Burany, A, Lakatos, M, Marton, J, Solymosi, A, Besznyak, I, Bursics, A, Papp, G, Saftics, G, Svastics, I, Valsdottir, E, Atladottir, J, Jonsson, T, Moller, P, Sigurdsson, H, Gupta, S, Kaul, N, Mohan, S, Sharma, G, Wani, R, Chowdri, N, Khan, M, Mehraj, A, Parray, F, Coveney, A, Burke, J, Deasy, J, El-Masry, S, Mcnamara, D, Cahill, R, Faul, E, Mulsow, J, Shields, C, Kelly, M, Bass, G, Martin, S, O'Connell, R, Ryan, E, Connelly, T, Ahmad, G, Bukhari, W, Cooke, F, Gold Deutch, R, Haim, N, Lavy, R, Moscovici, A, Shussman, N, Gefen, R, Marom, G, Pikarsky, A, Weiss, D, Avital, S, Hermann, N, Raguan, B, Slavin, M, White, I, Wasserberg, N, Arieli, H, Gurevich, N, Freund, M, Dorot, S, Edden, Y, Halfteck, G, Reissman, P, Pery, R, Tulchinsky, H, Weizman, A, Agresta, F, Curinga, R, Finotti, E, Savino, G, Verza, L, Asteria, C, Boccia, L, Pascariello, A, Tamini, N, Bugatti, A, Gianotti, L, Totis, M, Vincenti, L, Andriola, V, Giannini, I, Travaglio, E, Balestri, R, Buccianti, P, Roffi, N, Rossi, E, Urbani, L, Mellano, A, Cinquegrana, A, Lauretta, A, Belluco, C, Mistrangelo, M, Allaix, M, Arolfo, S, Morino, M, Testa, V, Delrio, P, Pace, U, Rega, D, Scala, D, Clerke, C, Clerico, G, Cornaglia, S, Realis Luc, A, Trompetto, M, Ugolini, G, Antonacci, N, Fabbri, S, Montroni, I, Zattoni, D, D'Urbano, C, Cornelli, A, Viti, M, Inama, M, Bacchion, M, Casaril, A, Impellizzeri, H, Moretto, G, Spinelli, A, Carvello, M, David, G, Di Candido, F, Sacchi, M, Frontali, A, Ceriani, V, Molteni, M, Rosati, R, Aleotti, F, Elmore, U, Lemma, M, Vignali, A, Scabini, S, Casoni Pattacini, G, Luzzi, A, Romairone, E, Marino, F, Lorusso, D, Pezzolla, F, Colombo, F, Baldi, C, Foschi, D, Sampietro, G, Sorrentino, L, Di Saverio, S, Birindelli, A, Segalini, E, Spacca, D, Romano, G, Belli, A, Bianco, F, De franciscis, S, Falato, A, Muratore, A, Marsanic, P, Grimaldi, S, Castaldo, N, Ciolli, M, Picarella, P, Porfidia, R, Tugnoli, G, Bondurri, A, Cavallo, D, Maffioli, A, Pertusati, A, Pulighe, F, Balestra, F, De Nisco, C, Podda, M, Opocher, E, Longhi, M, Mariani, N, Maroni, N, Pisani Ceretti, A, Galleano, R, Aonzo, P, Curletti, G, Reggiani, L, Marconi, M, Del Prete, L, Oldani, M, Pappalardo, R, Zaccone l, S, Scatizzi, M, Baraghini, M, Cantafio, S, Feroci, F, Giani, I, Tutino, R, Cocorullo, G, Gulotta, G, Licari, L, Salamone, G, Sileri, P, Saraceno, F, La Torre, F, Chirletti, P, Coletta, D, De Toma, G, Mingoli, A, Papandrea, M, De Luca, E, Sacco, R, Sammarco, G, Vescio, G, Tonini, V, Bianchini, S, Cervellera, M, Vaccari, S, Cracco, N, Barugola, G, Bertocchi, E, Rossini, R, Ruffo, G, Sartori, A, Clemente, N, De Luca, M, De Luca, A, Scaffidi, G, Lorenzon, L, Balducci, G, Bocchetti, T, Ferri, M, Mercantini, P, Bauce, S, Benevento, A, Bottini, C, Crapa, P, Rubbini, M, Anania, G, Carcoforo, P, Cavallesco, G, Feo, C, Yamamoto, T, Sivins, A, Ancans, G, Gerkis, S, Lunis, R, Pcolkins, A, Venskutonis, D, Bradulskis, S, Dainius, E, Subocius, A, Vencius, J, Zeromskas, P, Eismontas, V, Nutautiene, V, Simcikas, D, Tamosiunas, A, Svagzdys, S, Latkauskas, T, Lizdenis, P, Saladzinskas, Z, Tamelis, A, Dulskas, A, Kuliavas, J, Samalavicius, N, Poskus, T, Jotautas, V, Mikalauskas, S, Poskus, E, Strupas, K, Zakaria, A, Lah, N, Wong, M, Zain, W, Zakaria, Z, Mazlan, L, Mohd Azman, Z, Sagap, I, Psaila, J, Andrejevic, P, Cini, C, Ellul, S, Pace, K, Ahallat, M, Hamid, M, Hrora, A, Majbar, M, Raiss, M, Westerduin, E, Tanis, P, van der Sluis, P, Davids, P, Pronk, A, Schiphorst, A, Smakman, N, Zimmerman, D, Koeter, T, Stijns, J, van Loon, Y, Vermaas, M, de Graaf, E, Doornebosch, P, van Hagen, P, van Ruler, O, Toorenvliet, B, Nonner, J, van den Berg, I, van Steensel, L, Vles, W, Melenhorst, J, Orsini, R, Visschers, R, Hoff, C, Blom, R, Marsman, H, Mulder, I, Cense, H, de Castro, S, Demirkiran, A, Hunfeld, M, van Geloven, A, de Groof, J, Hendriks, E, Leeuwenburg, M, van Oorschot, N, Wit, F, Rupert, C, Veldman, P, Keijzers, M, Konsten, J, Den Boer, F, Corver, M, Boerma, E, Koolen, L, Martens, M, Van Wijck, K, Ignjatovic, D, Breuer, R, Gurpreet, B, Oresland, T, Tetens Moe, T, Nesbakken, A, Flaaten Backe, I, Wik, T, Radiya, K, Dehli, T, Gjessing, P, Norderval, S, Woll, K, Anwer, M, Qureshi, M, Qureshi, A, Billah, M, Jawad, M, Raza, A, Urooj, N, Wang, X, Li, L, Jajtner, D, Gasinski, B, Kabiesz, W, Walega, P, Romaniszyn, M, Zawadzki, M, Czarnecki, R, Obuszko, Z, Rzaca, M, Sitarska, M, Silva, P, Duarte, A, Goncalves, D, Morais, M, Rama, N, Nobre, J, Sales, I, Costa Pereira, J, Costa, S, Costa Pereira, C, Insua, C, Romero, I, Figueiredo, N, Cunha, J, Domingos, H, Vieira, P, Cunha, M, Americano, M, Amorim, E, Rachadell, J, Carvas, J, Armas, I, Fernandes, P, Pires, C, Reis, R, Martins, R, Dos Santos, M, Henriques, P, Oliveira, O, Duarte, M, Ferreira, L, Miranda, J, Vilela, N, Corte Real, J, Carlos, S, Frois Borges, M, Moniz Pereira, P, Simoes, J, Silva-vaz, P, Bettencourt, V, Gouveia, A, Perez, H, Rainho, R, Bintintan, V, Ciuce, C, Dindelegan, G, Scurtu, R, Seicean, R, Cristian, D, Burcos, T, Grama, F, Mandi, D, Richiteanu, G, Miron, A, Calu, V, Enciu, O, Nadragea, M, Parvuletu, R, Mogoanta, S, Crafciuc, A, Paitici, S, Beuran, M, Ciubotaru, C, Prodan, A, Vartic, M, Tomulescu, V, Copaescu, C, Yanishev, A, Abelevich, A, Kokobelyan, A, Lebedeva, M, Luzan, R, Pozdnyakov, A, Cherdancev, D, Mahotin, D, Nesytykh, A, Samsonyuk, V, Pravosudov, I, Ivlev, D, Karachun, A, Lebedev, K, Samsonov, D, Aiupov, R, Feoktistov, D, Garipov, M, Suleymanov, N, Tarasov, N, Rasulov, A, Dzhumabaev, H, Mamedli, Z, Bedzhanyan, A, Popov, D, Sednev, A, Klimenko, A, Semenov, A, Vasilyev, S, Khazov, A, Khanevich, M, Khrykov, G, Katorkin, S, Andreev, P, Chernov, A, Davidova, O, Zhuravlev, A, Achkasov, S, Shakhmatov, D, Shelygin, Y, Sushkov, O, Vardanyan, A, Ilkanich, A, Barbashinov, N, Darvin, V, Onishchenko, S, Voronin, Y, Krivokapic, Z, Barisic, G, Dimitrijevic, I, Markovic, V, Sekulic, A, Stanojevic, G, Brankovic, B, Nestorovic, M, Pecic, V, Petrovic, D, Kostic, I, Aleksic, A, Dabic, D, Maric, B, Perunicic, V, Radovanovic, Z, Djuric, M, Lukic, D, Radovanovic, D, Cuk, V, Juloski, J, Kenic, M, Krdzic, I, Ngu, J, Ng, Y, Teo, N, Korcek, J, Lazorisak, A, Rems, M, Ramovs Trampus, S, Tomazic, A, Grosek, J, Kosir, J, Norcic, G, Vigorita, V, Caceres, N, Casal, E, Ruano, A, Trostchansky, I, Golda, T, Galvez Saldana, A, Kreisler Moreno, E, Lopez Dominguez, J, Vila Tura, M, Labarga, F, Galvez, P, Maderuelo, V, Suero, C, Bargallo, J, Cayetano, L, Lamas, S, Silva, M, Bernal-Sprekelsen, J, Gomez, R, Jareno, S, Rios, A, Vercher, D, Garcia-Gonzalez, J, Cervera-Aldama, J, Ramos-Prada, J, Santamaria-Olabarrieta, M, Borda, N, Enrriquez-Navascues, J, Saralegui, Y, Calero-Lillo, A, Aznar-Puig, S, Lopez-Lara, M, Munoz-Collado, S, Valverde-Sintas, J, Menendez, P, Leon, C, Truan, N, Baldonedo, R, Fernandez-Martinez, D, Otero, J, Solar-Garcia, L, Turrado-Rodriguez, V, de Lacy Oliver, F, Lacy Fortuny, A, Martin Perez, B, Otero Pineiro, A, Paredes, J, Fernandez, F, Ladra, M, Paulos, A, Prieto, D, Beltran de Heredia, J, Blanco Antona, F, de Andres Asenjo, B, Ferreras Garcia, C, Romero de Diego, A, Cordoba Diaz de Laspra, E, Echazarreta Gallego, E, Elia Guedea, M, Escola, D, Martinez, S, Primo Romaguera, V, Parreno, R, Pastor, L, Rosell, E, Lozoya Trujillo, R, Alos Company, R, Ruiz Carmona, M, Solana Bueno, A, Salvans Ruiz, S, Alonso Goncalves, S, Jimenez- Toscano, M, Pascual Damieta, M, Pera Roman, M, Pellicer-Franco, E, Garcia-Marin, J, Mengual-Ballester, M, Soria-Aledo, V, Valero-Navarro, G, Vicente-Ruiz, M, Garcia-Zamora, C, Gonzalez-Gil, A, Montoya-Tabares, M, Paredes-Quiles, M, Die Trill, J, Abadia, P, Moreno, I, Pina, J, Ramos Rubio, D, Escartin, J, Blas, J, Fernando, J, Ferrer, R, Garcia Egea, J, Pros, I, Martinez, W, Rius, J, Socias, M, Sabia, D, Castellvi Valls, J, Gonzalez Santin, V, Mompart Garcia, S, Viso Pons, L, Julia, D, Codina-Cazador, A, Farres, R, Gomez, N, Planellas, P, Cuadrado, M, Camps, I, Rufas, M, Escoll, J, Ferminan, A, Muriel, P, Sierra, E, Alvarez-Laso, C, Lora, P, Padin, H, Garcia-Septiem, J, Bustamante, C, Jimenez, V, Jimenez-Miramon, J, Ramos, J, Gallardo, A, Benito, P, Colao, L, Galindo, P, Garcia, C, Forero-Torres, A, Alonso Poza, A, Dieguez Fernandez, B, Gilsanz Martin, C, Hernandez Garcia, M, Rojo Lopez, J, Gil Lopez, J, Gonzalez Zunzarren, M, Martinez Alegre, J, Zorrilla Matilla, L, Navarro-Sanchez, A, Alcala Serrano, F, Lopez-Fernandez, J, Montesdeoca Cabrera, D, Alvarez-Gallego, M, Guevara, J, Pascual Miguelanez, I, Rubio-Perez, I, Gomez Ruiz, M, Alonso Martin, J, Cagigas Fernandez, C, Castillo Diego, J, Pando, J, Maristany, C, Munoz-Duyos, A, Rada-Palomino, A, Vargas-Pierola, H, Pena Ros, E, Benavides Buleje, J, Munoz Camarena, J, Parra Banos, P, Ramirez Faraco, M, Arenal, J, Citores, M, Marcos, J, Sanchez, J, Tinoco, C, Garcia Florez, L, Arias Pacheco, R, Minguez Ruiz, G, Gutierrez Corral, N, Rodriguez Infante, A, Carrillo Lopez, M, Carrasco Prats, M, Lage Laredo, A, Martinez Manzano, A, Rodriguez Garcia, P, Segura-Sampedro, J, Alonso-Hernandez, N, Fernandez Isart, M, Gamundi Cuesta, M, Ochogavia Segui, A, Ibanez, N, Abrisqueta, J, Lujan, J, Gomez Perez, R, Corrales Valero, E, Monje Salazar, C, Sanchiz Cardenas, E, Soler Humanes, R, Jimenez-Rodriguez, R, De la Portilla, F, Diaz Pavon, J, Garcia Cabrera, A, Reyes Diaz, M, Espin, E, Marinello, F, Marti, M, Vallribera, F, Orts Mico, F, Ortin Navarro, M, Perez Climent, M, Serra Diaz, C, Millan, M, Caro, A, Escuder, J, Espina, B, Feliu, F, Climent Aira, A, Estevez Diz, A, Moreno Asencio, M, Varela Mato, A, Vazquez Bouzan, R, Diez-Alonso, M, Villeta-Plaza, R, Guadalajara, H, Alias, D, Garcia Olmo, D, Pastor, C, Valverde, I, Sanchez Romero, A, Gardea, A, Gil Santos, M, Nimmersgern, T, Serrano Paz, P, Romero-Simo, M, Blasco-Segura, T, Caravaca-Garcia, I, Costa-Navarro, D, Zarco-Pleguezuelos, A, Flor-Lorente, B, Garcia-Granero, A, Garcia-Granero, E, Arencibia, B, Alonso, J, Febles, G, Nogues, E, Roque, C, Segelman, J, Nygren, J, Nestler, G, Abraham-Nordling, M, Egenvall, M, Myrelid, P, Jung, B, Loftas, P, Lydrup, M, Azahr, N, Buchwald, P, Mangell, P, Syk, I, Nikberg, M, Carlander, J, Chabok, A, Smedh, K, Tiselius, C, Haapaniemi, S, Benckert, A, Adamina, M, Freil-Lanter, C, Gingert, C, Muller, P, Schafli, J, Regusci, L, Brenna, M, Fasolini, F, Misteli, H, Kirchhoff, P, Oertli, D, Hahnloser, D, Clerc, D, Hubner, M, Ris, F, Chevallay, M, Morel, P, Schiltz, B, Wang, J, Su, W, Huang, C, Ma, C, Tsai, H, Bugra, D, Agalar, F, Baloglu, H, Basoglu, I, Okkabaz, N, Binboga, E, Biricik, A, Celik, A, Yavuz, E, Canda, A, Agalar, C, Fuzun, M, Sokmen, S, Terzi, C, Isik, A, Karip, B, Bilgili, A, Leventoglu, S, Aytac, B, Kucukdiler, E, Yildiz, A, Yuksel, O, Sinan, H, Hancerliogullari, O, Kaymak, S, Kozak, O, Ozer, M, Sarici, I, Akca, O, Kalayci, M, Kara, Y, Agcaoglu, O, Balik, E, Bayram, O, Ozbalci, G, Ozkan, B, Karabacak, U, Sungurtekin, U, Ozgen, U, Demirbas, S, Ozturk, E, Isik, O, Yilmazlar, T, Colak, E, Karagul, S, Kinas, V, Fearnhead, N, Lord, I, Stewart, P, Zammit, M, Arnold, S, Broadhurst, J, Moran, S, Seretis, F, Shabbir, J, Jones, C, Kynaston, J, Vimalachandran, D, Blower, E, Mcfaul, C, Mcwhirter, D, Pilkington, J, Wilson, T, Chowdhary, M, Stubbs, B, Abdalkoddus, M, Lai, C, Thavanesan, N, Yao, C, Agarwal, T, Dindyal, S, Hill, R, Reade, S, Slesser, A, Paterson, H, Balfour, A, Boland, M, Geraghty, A, O'Kelly, J, Patel, P, Tezas, S, Yahia, S, Jadhav, V, Marimuthu, K, Narayanan, A, Piramanayagam, B, Bradley, N, Buchanan, F, Paul, K, Singh, J, Thomson, K, Korsgen, S, Bedford, M, Lee, K, Leong, K, Mcarthur, D, Malik, S, Mohamed, I, Cunha, P, Pilavas, A, Reddy, A, Ahmed, S, Ahmed, A, Voll, J, Velchuru, V, Lal, R, Mirshekar-Syahkal, B, Kassai, M, Aleem, M, Keogh-Bootland, S, Sarmah, P, Keegan, R, Kelkar, A, Sen, P, Oliveira-Cunha, M, Chaudhri, S, Fares, R, Thomas, W, Aslam, M, Boyle, K, Hemingway, D, Miller, A, Norwood, M, Gurjar, S, Al-Saeedi, M, Anandan, L, Sudlow, A, Zampitis, N, Malik, K, Bogdan, M, Smart, C, Iqbal, M, Bailey, S, Lawes, D, Omar, G, Tamhane, R, Evans, M, Ather, S, Lim, J, Nageswaran, H, Taylor, G, Hunt, L, Nicholls, J, Shaikh, I, Muscara, F, O'Brien, J, Photi, E, Stearns, A, Meylemans, D, Cunningham, C, Hompes, R, Tennakoon, A, Kumarasinghe, N, Rao, M, Upanishad, I, Khan, J, Ahmad, N, Shweejawee, Z, Stefan, S, Smart, N, Daniels, I, Gregoir, T, Longstaff, L, Mcdermott, F, Varcada, M, Drami, I, Gala, T, Moggia, E, Ratnatunga, K, Harries, R, Hayes, J, Williams, G, Raymond, T, Bronder, C, Davies, E, Hawkin, P, Ryska, O, Ayral, K, Beveridge, A, Bhowmik, A, Gill, M, Simpson, R, Schofield, A, Mcardle, K, Parmar, M, Williamson, M, Burton, H, Courtney, E, Grant, C, Saracino, A, Newton, K, Epstein, J, Branagan, G, Bignell, M, Symankewicz, M, Zaman, S, Mankotia, R, Siddiqui, Z, Torrance, A, Artioukh, D, Eggleston, M, Gokul, K, Selwyn, D, Warusavitarne, J, Chandrasinghe, P, Grainger, J, Leo, C, Harris, G, Levy, B, Skull, A, Thaha, M, Garg, A, Patel, H, Ramsanahie, A, Mondragon-Pritchard, M, Cuinas Leon, K, Shukla, A, Brewer, H, Fitzgerald, J, Kho, H, Torkington, J, Tate, S, Wheat, J, Smolarek, S, Platt, E, Rossi, B, Tham, J, Knight, J, Richardson, J, Tzivanakis, A, Gregori, M, Ashraf, M, Atif, M, Santos, J, Saffaf, N, Canning, L, Chandratreya, N, Bowen, M, Graham, B, Hamad, Y, Kaubrys, M, Chaudhry, Z, Bhan, C, Mukhtar, H, Oshowo, A, Wilson, J, Gouvas, N, Nicol, D, Pandey, S, Zilvetti, M, Sharma, A, Fatayer, T, Mothe, S, Rahman, M, Curtis, N, Allison, A, Dalton, R, Francis, N, Ockrim, J, Psaras, G, Dudarovaska, H, Marharint, T, Mostovoy, E, Voloshin, S, Kolesnik, O, Makhmudov, D, Altinel, Y, Iqbal, A, Cunningham, L, Go, K, Tan, S, R. Tutino, G. Salamone, L. Licari, G. Cocorullo, G. Gulotta
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Colorectal cancer
deferral of surgery
neoadjuvant therapy
pathology
radiology
rectal cancer
Rectal surgery
surgical oncology
Gastroenterology
0302 clinical medicine
Prospective Studies
Prospective cohort study
Complete response
Medical Audit
integumentary system
Incidence (epidemiology)
Incidence
Remission Induction
Middle Aged
Magnetic Resonance Imaging
Europe
Treatment Outcome
Response Evaluation Criteria in Solid Tumors
030220 oncology & carcinogenesis
Preoperative Period
030211 gastroenterology & hepatology
Female
Adult
medicine.medical_specialty
NO
03 medical and health sciences
medicine
Humans
Intensive care medicine
Deferral
Pathological
Aged
Neoplasm Staging
ta3126
business.industry
Rectal Neoplasms
Reproducibility of Results
Chemoradiotherapy
Adjuvant
medicine.disease
Rectal Neoplasms/diagnostic imaging
Neoplasm Staging/methods
business
Zdroj: El-Hussuna, A, Ceccotti, A A, Madsbøll, T K, Straarup, D, Ovesen, A U & 2017 European Society of Coloproctology (ESCP) collaborating group 2018, ' Evaluating the incidence of pathological complete response in current international rectal cancer practice : the barriers to widespread safe deferral of surgery ', Colorectal Disease, vol. 20, no. Suppl. 6, pp. 58-68 . https://doi.org/10.1111/codi.14361
Christensen, P & 2017 European Society of Coloproctology (ESCP) collaborating group 2018, ' Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery ', Colorectal Disease, vol. 20 Suppl 6, pp. 58-68 . https://doi.org/10.1111/codi.14361
DOI: 10.1111/codi.14361
Popis: INTRODUCTION: The mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). We aim to report the overall complete pathological response (pCR) rate and the reliability of detecting a cCR by conventional pre-operative imaging.METHODS: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients treated by elective rectal resection were included. A pCR was defined as a ypT0 N0 EMVI negative primary tumour; a partial response represented any regression from baseline staging following chemoradiotherapy. The primary endpoint was the pCR rate. The secondary endpoint was agreement between post-treatment MRI restaging (yMRI) and final pathological staging.RESULTS: Of 2572 patients undergoing rectal cancer surgery in 277 participating centres across 44 countries, 673 (26.2%) underwent chemoradiotherapy and surgery. The pCR rate was 10.3% (67/649), with a partial response in 35.9% (233/649) patients. Comparison of AJCC stage determined by post-treatment yMRI with final pathology showed understaging in 13% (55/429) and overstaging in 34% (148/429). Agreement between yMRI and final pathology for T-stage, N-stage, or AJCC status were each graded as 'fair' only (n = 429, Kappa 0.25, 0.26 and 0.35 respectively).CONCLUSION: The reported pCR rate of 10% highlights the potential for non-operative management in selected cases. The limited strength of agreement between basic conventional post-chemoradiotherapy imaging assessment techniques and pathology suggest alternative markers of response should be considered, in the context of controlled clinical trials.
Databáze: OpenAIRE
Externí odkaz: