Individualized significance of the -251 A/T single nucleotide polymorphism of interleukin-8 in severe infections
| Autor: | Mihai G. Netea, G. Kouliatsis, Antonia Koutsoukou, Dimitrios Velissaris, Iraklis Tsangaris, Konstantinos Leventogiannis, Marianna Georgitsi, O. Dioritou-Aggaliadou, Zoi Alexiou, E. Aimoniotou, C. Panou, Nikolaos K. Gatselis, V. Vitoros, Efthymia Giannitsioti, E. Belesiotou, George Giannikopoulos, N. Voloudakis, E. Chasou, Evangelos J. Giamarellos-Bourboulis |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Pathology Adolescent Genotype lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] Single-nucleotide polymorphism Polymorphism Single Nucleotide Gastroenterology Sepsis Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Genetic Predisposition to Disease Genotyping Aged Aged 80 and over Septic shock business.industry Interleukin-8 Interleukin 030208 emergency & critical care medicine Bacterial Infections General Medicine Odds ratio Middle Aged medicine.disease Infectious Diseases 030220 oncology & carcinogenesis Bacteremia Female business |
| Zdroj: | European Journal of Clinical Microbiology and Infectious Diseases, 35, 563-70 European Journal of Clinical Microbiology and Infectious Diseases, 35, 4, pp. 563-70 |
| ISSN: | 0934-9723 |
| Popis: | Contains fulltext : 172802.pdf (Publisher’s version ) (Closed access) Based on the concept of the individualized nature of sepsis, we investigated the significance of the -251 A/T (rs4073) single nucleotide polymorphism (SNP) of interleukin (IL)-8 in relation to the underlying infection. Genotyping was performed in 479 patients with severe acute pyelonephritis (UTI, n = 146), community-acquired pneumonia (CAP, n = 109), intra-abdominal infections (IAI, n = 119), and primary bacteremia (BSI, n = 105) by restriction fragment length polymorphism of the polymerase chain reaction (PCR) product and compared with 104 healthy volunteers. Circulating IL-8 was measured within the first 24 h of diagnosis by an immunosorbent assay. Carriage of the AA genotype was protective from the development of UTI (odds ratio 0.38, p: 0.007) and CAP (odds ratio 0.30, p: 0.004), but not from IAI and BSI. Protection from the development of severe sepsis/septic shock was provided for carriers of the AA genotype among patients with UTI (odds ratio 0.15, p: 0.015). This was accompanied by greater concentrations of circulating IL-8 among patients with the AA genotype. It is concluded that carriage of rs4073 modifies susceptibility for severe infection in an individualized way. This is associated with a modulation of circulating IL-8. |
| Databáze: | OpenAIRE |
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