Effect of natural antiphospholipid antibodies on antithrombotic activity of vascular wall
| Autor: | I. V. Lekakh, L. V. Lyubina, L. V. Panarina, V. N. Romanovskaya, Alexander E. Kabakov, A. M. Povernnyii, V. M. Zyablitskii |
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| Rok vydání: | 1999 |
| Předmět: |
Vascular wall
Endothelium Platelet Aggregation Pharmacology Inferior vena cava General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Antiphospholipid syndrome Antithrombotic Cardiolipin Cell Adhesion Medicine Humans cardiovascular diseases Aorta Cells Cultured biology business.industry Thrombosis General Medicine medicine.disease Aortic wall medicine.anatomical_structure medicine.vein chemistry Immunology cardiovascular system biology.protein Antibodies Antiphospholipid Endothelium Vascular Antibody business |
| Zdroj: | Bulletin of experimental biology and medicine. 129(4) |
| ISSN: | 0007-4888 |
| Popis: | Natural latent human antibodies cross-reacting with DNA and cardiolipin, interact with human endothelial cells, decrease antiaggregation activity of rat aortic wall, and increase fibrinolytic activity of the wall of the inferior vena cava. It is assumed that natural antiphospholipid antibodies present in immunoglobulin preparations in a latent state modify antithrombogenic activity of the vascular wall and are a potential cause of antiphospholipid syndrome. |
| Databáze: | OpenAIRE |
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