Reduced perfusion density of superficial retinal capillary plexus after intravitreal ocriplasmin injection for idiopathic vitreomacular traction
| Autor: | Giovanni Fogliato, Riccardo Sacconi, Marco Codenotti, Francesco Bandello, Lorenzo Iuliano, Roberta Colombo, Giuseppe Querques |
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| Přispěvatelé: | Iuliano, L., Fogliato, G., Colombo, R., Sacconi, R., Querques, G., Bandello, F., Codenotti, M. |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty genetic structures Vitreomacular traction Pilot Projects Foveal avascular zone Vitreous Detachment chemistry.chemical_compound lcsh:Ophthalmology Peptide Fragment Ophthalmology Retinal capillary medicine Humans Macula Lutea Pilot Project Fibrinolysin Aged Plexus business.industry Intravitreal Injection Ocriplasmin Ocriplasmin Injection OCT angiography Small sample General Medicine Middle Aged Retinal Perforations Peptide Fragments eye diseases Perfusion density chemistry lcsh:RE1-994 Regional Blood Flow Case-Control Studies Intravitreal Injections Retinal Perforation Female sense organs Case-Control Studie business Perfusion Research Article Human |
| Zdroj: | BMC Ophthalmology, Vol 19, Iss 1, Pp 1-11 (2019) BMC Ophthalmology |
| ISSN: | 1471-2415 |
| Popis: | Background To investigate, using optical coherence tomography angiography (OCT-A), changes in perfusion density and in the foveal avascular zone (FAZ) in eyes with idiopathic vitreomacular traction (VMT) after ocriplasmin injection. Methods In this pilot study, we enrolled sixteen VMT eyes treated with intravitreal ocriplasmin injection. Sixteen healthy eyes were considered as controls. Macular perfusion density in 3 plexuses [superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC)] was calculated at baseline and at 1 month after injection. Results After injection, VMT anatomically resolved in 9 eyes (56.2%), whereas 7 eyes (43.8%) achieved an incomplete VMT separation. Superficial capillary plexus perfusion density was reduced significantly after injection (from 0.427 ± 0.027 to 0.413 ± 0.028; p = 0.0146), while no differences were noted in the DCP (p = 0.2717) nor in the CC (p = 0.6848). Study-eye perfusion density was statistically similar to control eyes in all three plexuses, both at baseline and at follow-up. The FAZ in the SCP area remained unchanged after injection (p = 0.168) but was significantly inferior to controls both at baseline and at 1 month (0.198 ± 0.074 vs. 0.196 ± 0.070; p = 0.007). Conclusions Eyes with VMT have a perfusion density comparable to healthy controls, but a smaller FAZ. After ocriplasmin injection the perfusion density in the SCP is reduced, regardless the anatomical success. Limited by the small sample size and the pilot nature of the study, we found microvascular changes after ocriplasmin injection, which may be due to retinal traction release. |
| Databáze: | OpenAIRE |
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