High-frequency Percussive Ventilation for Airway Clearance in Cystic Fibrosis: A Brief Report
| Autor: | Dayton Dmello, Ravi P. Nayak, George M. Matuschak |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Cystic Fibrosis High-Frequency Ventilation Cystic fibrosis Hypercarbia Humans Medicine Lung business.industry Sputum Oxygenation Carbon Dioxide Hypoxia (medical) medicine.disease Radiography Treatment Outcome medicine.anatomical_structure Respiratory failure Anesthesia Breathing Acidosis Respiratory medicine.symptom business Perfusion |
| Zdroj: | Lung. 188:511-513 |
| ISSN: | 1432-1750 0341-2040 |
| DOI: | 10.1007/s00408-010-9252-5 |
| Popis: | Exacerbations of cystic fibrosis (CF) lung dis- ease are characterized by increased inspissation of abnor- mally viscid pulmonary secretions with resultant plugging of small airways, worsened ventilation/perfusion mismatch, and increased physiological deadspace. In this circumstance, hypoxic respiratory failure necessitating mechanical venti- lation can be life-threatening. We present such a case of CF lung disease poorly responsive to conventional mechanical ventilatory strategies, in which high-frequency percussive ventilation (HFPV) using volumetric diffusive respiration mobilized copious amounts of inspissated pulmonary secre- tions and improved refractory hypoxia. Subsequent transient hypercarbia necessitated titrating ventilator parameters to return the PaCO2 to baseline; the voluminous clearance of secretions and improvement in oxygenation were sustained. HFPV appears unique in its ability to function as a meth- odological continuum from noninvasive percussion to invasive percussive ventilation for airway clearance, a fun- damental tenet of the CF treatment paradigm. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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