The effect of olive leaf extract on cardiovascular health markers

Autor: Bjorn Winkens, Yala Stevens, Daisy Jonkers, Adrian A. M. Masclee
Přispěvatelé: Interne Geneeskunde, RS: NUTRIM - R2 - Liver and digestive health, FHML Methodologie & Statistiek, RS: CAPHRI - R6 - Promoting Health & Personalised Care, MUMC+: MA Maag Darm Lever (9)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Adult
medicine.medical_specialty
medicine.medical_treatment
OLEA-EUROPAEA L
Medicine (miscellaneous)
Blood lipids
030204 cardiovascular system & hematology
Overweight
METABOLISM
Placebo
Gastroenterology
DISEASE
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Double-Blind Method
Olive leaf extract
Internal medicine
Olea
medicine
Humans
METAANALYSIS
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Cholesterol
Plant Extracts
Insulin
MORTALITY
OLEUROPEIN
CONSUMPTION
Original Contribution
medicine.disease
Cardiovascular disease
Blood lipid profiles
MEDITERRANEAN DIET
LIPOPROTEIN-CHOLESTEROL RATIO
Blood pressure
chemistry
OBESITY
Dietary Supplements
Liver function
FATTY-ACIDS
medicine.symptom
business
Dyslipidemia
Biomarkers
Zdroj: European Journal of Nutrition
European Journal of Nutrition, 60(4), 2111-2120. Springer
ISSN: 1436-6215
1436-6207
Popis: Purpose Overweight and obesity are associated with many health problems, including cardiovascular disease (CVD). Evidence from previous studies has shown that extracts from olive leaves rich in olive phenolics are able to positively affect CVD risk factors, such as high blood pressure and dyslipidemia. The aim of this study was to investigate the effect of 8-week olive leaf extract (OLE) administration on blood lipid profiles in overweight/obese subjects with mildly elevated cholesterol levels. Methods In this randomized, double-blind, placebo-controlled study, 77 healthy adult overweight/obese subjects (aged 56 ± 10 years and BMI 29.0 ± 2.7 kg/m2) with total cholesterol levels of 5.0–8.0 mmol/L (5.9 ± 0.7 mmol/L) were randomly assigned to receive 500 mg of OLE (n = 39) or placebo (n = 38) for 8 weeks. In total, 74 subjects completed the entire study protocol. At baseline, after 4 weeks, and after 8 weeks of supplementation, blood lipid profiles, oxidized low-density lipoprotein (oxLDL), blood pressure, glucose, and insulin levels were assessed. In addition, liver function parameters were measured at baseline and after 8 weeks. Results OLE supplementation did not significantly affect blood lipid levels after 4 weeks or after 8 weeks compared to placebo (all p > 0.05). For oxLDL, blood pressure, glucose, and insulin levels and liver function parameters, also no statistically significant differences were found between the two intervention groups (all p > 0.05). Conclusions Blood lipid profiles were not significantly affected by 8 weeks OLE supplementation in overweight/obese subjects with mildly elevated cholesterol levels. Trial registered The trial has been registered at ClinicalTrials.gov (NCT02990637).
Databáze: OpenAIRE
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