Score to identify the severity of adult patients with influenza A (H1N1) 2009 virus infection at hospital admission

Autor: A, Capelastegui, J M, Quintana, A, Bilbao, P P, España, O, Garin, J, Alonso, J, Astray, R, Cantón, J, Castilla, A, Castro, M, Delgado-Rodríguez, P, Godoy, F, Gónzález-Candelas, V, Martín, J M, Mayoral, T, Pumarola, S, Tamames, N, Soldevila, M, Baricot, A, Domínguez, Eva, Tato
Rok vydání: 2012
Předmět:
Adult
Male
Microbiology (medical)
medicine.medical_specialty
Chronic Obstructive Pulmonary Disease
Comorbidity
medicine.disease_cause
Severity of Illness Index
Article
Body Mass Index
Seasonal Influenza
Influenza A Virus
H1N1 Subtype
Pregnancy
Risk Factors
Internal medicine
Influenza
Human
Severity of illness
Odds Ratio
medicine
Influenza A virus
Humans
Intensive Care Unit Admission
Prospective Studies
Prospective cohort study
Aged
Respiratory Distress Syndrome
Framingham Risk Score
Septic shock
business.industry
Computational Biology
General Medicine
Odds ratio
Middle Aged
Prognosis
medicine.disease
Respiration
Artificial
Shock
Septic
Influenza
Surgery
Hospitalization
Pneumonia
Infectious Diseases
ROC Curve
Case-Control Studies
Multivariate Analysis
Female
Influenza Epidemic
business
Cohort study
Zdroj: European Journal of Clinical Microbiology & Infectious Diseases
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
r-FISABIO. Repositorio Institucional de Producción Científica
instname
ISSN: 1435-4373
0934-9723
DOI: 10.1007/s10096-012-1616-8
Popis: The objective of this paper was to develop a prognostic index for severe complications among hospitalized patients with influenza A (H1N1) 2009 virus infection. We conducted a prospective observational cohort study of 618 inpatients with 2009 H1N1 virus infection admitted to 36 Spanish hospitals between July 2009 and February 2010. Risk factors evaluated included host-related factors and clinical data at admission. We developed a composite index of severe in-hospital complications (SIHC), which included: mortality, mechanical ventilation, septic shock, acute respiratory distress syndrome, and requirement for resuscitation maneuvers. Six factors were independently associated with SIHC: age > 45 years, male sex, number of comorbidities, pneumonia, dyspnea, and confusion. From the beta parameter obtained in the multivariate model, a weight was assigned to each factor to compute the individual influenza risk score. The score shows an area under the receiver operating characteristic (ROC) curve of 0.77. The SIHC rate was 1.9 % in the low-risk group, 10.3 % in the intermediate-risk group, and 29.6 % in the high-risk group. The odds ratio for complications was 21.8 for the high-risk group compared with the low-risk group. This easy-to-score influenza A (H1N1) 2009 virus infection risk index accurately stratifies patients hospitalized for H1N1 virus infection into low-, intermediate-, and high-risk groups for SIHC.
Databáze: OpenAIRE
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