Changes in liver structure and function after short-term and long-term treatment of rats with dehydroepiandrosterone
| Autor: | Monica Bellei, Valentina Bobyleva, Umberto Muscatello, Henry A. Lardy, Daniela Battelli, Claudio Fornieri, Giuseppe Mori |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Inbred Strains Medicine (miscellaneous) Dehydroepiandrosterone Administration Oral Mitochondrion Biology Oral Animals Body Weight/drug effects Dehydroepiandrosterone/administration & dosage/*toxicity Dose-Response Relationship Microbodies Muscle hypertrophy Internal medicine Respiration medicine Animals Nutrition and Dietetics Dose-Response Relationship Drug Body Weight Rats Inbred Strains Metabolism Administration Drug Hepatomegaly/chemically induced Liver/*drug effects/ultrastructure Male Microbodies/drug effects/ultrastructure Organ Size/drug effects Rats Rats Organ Size Peroxisome Rats Steroid hormone Endocrinology Liver Toxicity Hepatomegaly |
| Zdroj: | The Journal of nutrition. 122(4) |
| ISSN: | 0022-3166 |
| Popis: | The effects on the liver of feeding a diet containing 0.2% dehydroepiandrosterone were studied after short (7 d) and long (100 d) periods of treatment in rats. The short-term treatment caused hypertrophy of the hepatocytes that, at the ultrastructural level, seemed to be due to proliferation of peroxisomes and (to a minor extent) of mitochondria. The mitochondria seemed to have undergone transition from expanded to condensed configuration; accordingly, after isolation, their rate of coupled respiration was greater than that of control mitochondria. After long-term treatment, the structure of the hepatocytes reverted toward normal. In fact, at the ultrastructural level, the number and the size of peroxisomes was not significantly different from those of the controls, but degenerative phenomena were observed in the mitochondria. Attempts are made to explain the above ultrastructural and biochemical findings in view of the effects of dehydroepiandrosterone on the energy metabolism of liver. |
| Databáze: | OpenAIRE |
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