Multilocus genetic risk score for diabetic retinopathy in the Han Chinese population of Taiwan
| Autor: | Wen-Lu Chen, Wen Ling Liao, Jang Ming Lin, Ming-Chia Hsieh, Ya-Wen Chang, Yu Chuen Huang, Fuu Jen Tsai, Chia-Ming Wu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Population Taiwan lcsh:Medicine 030209 endocrinology & metabolism Single-nucleotide polymorphism Genome-wide association study Logistic regression Polymorphism Single Nucleotide Article 03 medical and health sciences 0302 clinical medicine Asian People Risk Factors Polymorphism (computer science) Internal medicine Genetic variation Humans Medicine Genetic Predisposition to Disease lcsh:Science education Aged education.field_of_study Diabetic Retinopathy Multidisciplinary business.industry lcsh:R fungi Area under the curve Diabetic retinopathy Middle Aged medicine.disease 030221 ophthalmology & optometry Female lcsh:Q business Genome-Wide Association Study |
| Zdroj: | Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The aim of this study is to explore the effect of genetic variation on diabetic retinopathy (DR) risk in a Taiwanese population. The logistic regression model was used to evaluate the relationship between DR status and risk factors, including the conventional parameters and genetic risk score (GRS). Candidate single nucleotide polymorphisms (SNPs) in GRS were selected based on previous reports with a combined P −4 (genome-wide association) and P P P = 0.0024) and improving the sensitivity of the model such that 40 more subjects were reclassified into DR status. The developed multivariate logistic regression model combining conventional risk factors and the multilocus GRS can predict DR, thus enabling timely treatment to reduce blindness in T2D patients. |
| Databáze: | OpenAIRE |
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