Non-reversible heat-induced gelation of a biocompatible Fmoc-hexapeptide in water
| Autor: | Pall Thordarson, Eric Y. Du, Jonathan P. Wojciechowski, Robert E. Nordon, Adam D. Martin, Christopher J. Garvey |
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| Rok vydání: | 2020 |
| Předmět: |
Heat induced
Hot Temperature Biocompatibility Injectable hydrogels Nanofibers Biocompatible Materials 02 engineering and technology 010402 general chemistry 01 natural sciences Divalent Cell Line Mice Drug Delivery Systems Tissue engineering Cations Animals General Materials Science Hydrophobic collapse chemistry.chemical_classification Fluorenes Molecular Structure Chemistry Hydrogels 021001 nanoscience & nanotechnology Biocompatible material 0104 chemical sciences Molecular Weight Kinetics Chemical engineering Drug delivery 0210 nano-technology Rheology Hydrophobic and Hydrophilic Interactions Oligopeptides |
| Zdroj: | Nanoscale. 12(15) |
| ISSN: | 2040-3372 |
| Popis: | Hydrogel materials which respond to changes in temperature are widely applicable for injectable drug delivery or tissue engineering applications. Here, we report the unsual heat-induced gelation behaviour of a low molecular weight gelator based on an Fmoc-hexapeptide, Fmoc-GFFRGD. We show that Fmoc-GFFRGD forms kinetically stable fibres when mixed with divalent cations (e.g. Ca2+). Gelation of the mixture occurs upon heating of the mixture which enables electrostatic screening by the divalent cations and hydrophobic collapse of the fibres to give a self-supporting hydrogel network that shows good biocompatibility with L929 fibroblast cells. This work highlights a unique mechanism to initiate heat-induced gelation which should find opportunities as a gelation trigger for injectable hydrogels or fundamental self-assembly applications. |
| Databáze: | OpenAIRE |
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