Evaluation of the clinical performance of a new intradermal vaccine administration technique and associated delivery system
| Autor: | Stephane Bonnet, John A. Mikszta, Philippe Emile Fernand Laurent, Paul G. Alchas, Noel G. Harvey, Ronald J. Pettis, Paulina Regolini |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Injections Intradermal Microinjections Swine Vaccine administration Injection site Animals Humans Medicine Medical physics Intradermal injection Aged Skin Ultrasonography Histological examination Aged 80 and over Vaccines General Veterinary General Immunology and Microbiology business.industry Public Health Environmental and Occupational Health Clinical performance Vaccine delivery Middle Aged Surgery Radiography Vaccination Infectious Diseases Equipment and Supplies Molecular Medicine Female Delivery system business |
| Zdroj: | Vaccine. 25:8833-8842 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2007.10.020 |
| Popis: | The advantages of intradermal (ID) vaccine administration have been well documented but difficulties in performing ID vaccination using existing techniques and equipment have limited it's clinical application. In the present study, a new ID injection technique and associated microinjection system is described and evaluated in a swine and Human models. Clinical investigation models included: injection site imaging (X-ray and 3D ultrasound echography), histological examination of injection sites, fluid injection volume accuracy measurement, subject' perceived pain and local skin reactivity were specifically developed. These evaluations showed that microinjection system can make the practice of ID vaccination easy to perform, reliable and safe, thus setting the stage for broader clinical application of ID vaccine delivery. |
| Databáze: | OpenAIRE |
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