Lead Compounds from Mangrove-Associated Microorganisms
| Autor: | Peter Proksch, Georgios Daletos, Elena Ancheeva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Antifungal
Antifungal Agents medicine.drug_class Microorganism Pharmaceutical Science Antineoplastic Agents endophytes Review Biology drug leads 01 natural sciences Antiviral Agents Biological Factors Lead (geology) Botany Drug Discovery medicine Glycoside Hydrolase Inhibitors Mangrove ecosystem Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 Soil Microbiology Ecological niche Mangrove plants Bacteria 010405 organic chemistry Receptor-Like Protein Tyrosine Phosphatases Class 5 Fungi Biodiversity Plants Biodiversity hotspot mangrove microorganisms 0104 chemical sciences Anti-Bacterial Agents 010404 medicinal & biomolecular chemistry lcsh:Biology (General) Wetlands bioactive natural products Mangrove |
| Zdroj: | Marine Drugs, Vol 16, Iss 9, p 319 (2018) Marine Drugs |
| ISSN: | 1660-3397 |
| Popis: | The mangrove ecosystem is considered as an attractive biodiversity hotspot that is intensively studied in the hope of discovering new useful chemical scaffolds, including those with potential medicinal application. In the past two decades, mangrove-derived microorganisms, along with mangrove plants, proved to be rich sources of bioactive secondary metabolites as exemplified by the constant rise in the number of publications, which suggests the great potential of this important ecological niche. The present review summarizes selected examples of bioactive compounds either from mangrove endophytes or from soil-derived mangrove fungi and bacteria, covering the literature from 2014 to March 2018. Accordingly, 163 natural products are described in this review, possessing a wide range of potent bioactivities, such as cytotoxic, antibacterial, antifungal, α-glucosidase inhibitory, protein tyrosine phosphatase B inhibitory, and antiviral activities, among others. |
| Databáze: | OpenAIRE |
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