Activated Akt as an indicator of prognosis in gastric cancer
| Autor: | Carla Vindigni, Dario La Sala, Daniele Marrelli, Piero Tosi, Maria Carmela Epistolato, Caterina Cinti, Alessandra Zamparelli, Gabriele Cevenini |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Cyclin E Mitotic index Survival Ubiquitin-Protein Ligases pAkt Apoptosis Pathology and Forensic Medicine Cyclin D1 Stomach Neoplasms CDC2 Protein Kinase medicine Biomarkers Tumor Humans Molecular Biology Protein kinase B Aged Cell Proliferation Retrospective Studies Aged 80 and over Cyclin-dependent kinase 1 business.industry Akt Cancer Cell Biology General Medicine Cell cycle Middle Aged medicine.disease Prognosis Tumor progression Survival Analysis Gastric cancer Cancer research Disease Progression Female business Proto-Oncogene Proteins c-akt Cyclin-Dependent Kinase Inhibitor p27 |
| Zdroj: | Virchows Archiv : an international journal of pathology. 453(5) |
| ISSN: | 0945-6317 |
| Popis: | The immunohistochemical expression of phosphorylated (activated) Akt (pAkt) in 50 advanced gastric carcinomas has been analyzed and the results correlated with age, sex, location in the stomach, histotype, stage, survival, mitotic and apoptotic index, some cell cycle regulators (cyclin D1, cyclin E, p34/cdc2, p27/kip1), and cell proliferation. There was a statistically significant direct correlation between pAkt expression (both cytoplasmatic and nuclear) and depth of infiltration of the tumor, number of infiltrated lymph nodes and p34/cdc2 expression, and between prevalently nuclear pAkt and cyclin D1 and cyclin E. Conversely, there was a significant inverse correlation between nuclear pAkt and apoptotic index and between cytoplasmatic and nuclear pAkt and patient survival. No correlation was found between pAkt and sex, age, tumor location, histotype, mitotic index, and cell proliferation. These findings suggest that pAkt may be considered an indicator of tumor progression and patient survival in gastric cancer. |
| Databáze: | OpenAIRE |
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