Clinical efficacy of combined topical 0.05% cyclosporine A and 0.1% sodium hyaluronate in the dry eyes with meibomian gland dysfunction
| Autor: | Ha-Na Oh, Sang-Youp Han, Jong Soo Lee, Ji Eun Lee, Ju-Whan Song, Ho-Yun Kim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty genetic structures Sodium hyaluronate Meibomian gland dry eye 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:Ophthalmology Clinical Research Ophthalmology medicine Ocular Surface Disease Index 0.1% hyauronate Telangiectasia Massage business.industry Dry eyes Meibomian gland dysfunction Repeated measures design meibomian gland dysfunction medicine.disease eye diseases 030104 developmental biology medicine.anatomical_structure chemistry lcsh:RE1-994 0.05% cyclosporine 030221 ophthalmology & optometry sense organs medicine.symptom business |
| Zdroj: | International Journal of Ophthalmology, Vol 11, Iss 4, Pp 593-600 (2018) |
| ISSN: | 2227-4898 2222-3959 |
| DOI: | 10.18240/ijo.2018.04.09 |
| Popis: | AIM: To investigate the efficacy of combined topical 0.05% cyclosporine A (CsA; Restasis®, Allergan pharmaceuticals, USA) and 0.1% sodium hyaluronate treatment in dry eyes with meibomian gland dysfunction (MGD). METHODS: In a retrospective analysis, 53 patients (106 eyes) with MGD were enrolled and performed lid warm massage for 10min daily and be instilled preservative free sodium hyaluronate 0.1% eye drops 4 times daily. Patients were divided into subjects treated with topical 0.05% CsA and preservative free sodium hyaluronate vehicle (experimental group, n=74 eyes) and subjects treated with the preservative free sodium hyaluronate vehicle (control group, n=32 eyes). They were evaluated at baseline and 1, 2, and 3mo for subjective symptoms and objective signs including tear film break-up time (tBUT), Schirmer test, corneal staining (CS) score, lid margin telangiectasia (LMT), meibomian gland secretion (MGS), and conjunctival injection (CI). RESULTS: In the short-term treatment, the experimental group showed a statistically significant improvement in the ocular surface disease index (OSDI; P |
| Databáze: | OpenAIRE |
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