Carboplatin (Paraplatin; JM8) and etoposide (VP-16) as first-line combination therapy for small-cell lung cancer
| Autor: | B D Evans, John Yarnold, I.E. Smith, M E Gore, H. T. Ford, L. Repetto, M D Vincent |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Lung Neoplasms Time Factors Organoplatinum Compounds Combination therapy Gastroenterology Drug Administration Schedule Carboplatin chemistry.chemical_compound Ototoxicity Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Carcinoma Small Cell Etoposide Aged Clinical Trials as Topic Lung business.industry Middle Aged medicine.disease Surgery Clinical trial medicine.anatomical_structure Oncology chemistry Toxicity Female business medicine.drug |
| Zdroj: | Journal of Clinical Oncology. 5:185-189 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.1987.5.2.185 |
| Popis: | Fifty-two previously untreated patients with small-cell lung carcinoma (SCLC) were treated with a combination of carboplatin 300 mg/m2 intravenously (IV) on day 1 and etoposide 100 mg/m2 IV on days 1 through 3 every 28 days for four courses. Patients with limited disease (LD) subsequently received thoracic radiotherapy; no prophylactic cranial radiotherapy was used. Forty-four patients (85%) achieved an objective response, including 82% (29% complete remissions) of LD patients and 88% (13% complete remissions) of extensive-disease (ED) patients. Median response duration for LD patients was 7 months and 5.5 months for ED patients. Median survival for both LD and ED patients was 9.5 months. Myelosuppression was the main toxicity, with World Health Organization (WHO) grade 3/4 leucopenia occurring in 44% of patients. There was one (2%) treatment-related neutropenic death. Treatment was otherwise well tolerated, and in particular no renal toxicity, neurotoxicity, or ototoxicity was seen. This new combination is highly active in terms of response rate, but response duration and survival is disappointing, and might be improved by prolonged treatment or by the use of additional drugs in combination. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|