A Polymorphism of the YTHDF2 Gene (1p35) Located in an Alu-Rich Genomic Domain Is Associated With Human Longevity
| Autor: | Elena Mugianesi, Rosamaria Lisa, Raffaella Moresi, Luca Cavallone, Simona Giovagnetti, Claudio Franceschi, Maurizio Cardelli, Fabiola Olivieri, Francesca Marchegiani |
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| Přispěvatelé: | Cardelli M., Marchegiani F., Cavallone L., Olivieri F., Giovagnetti S., Mugianesi E., Moresi R., Lisa R., Franceschi C. |
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Aging Adolescent Genotype Longevity Alu element Locus (genetics) Biology Alu Elements Humans Lymphocytes RNA Messenger Allele Genotyping Aged Aged 80 and over Genetics Messenger RNA Polymorphism Genetic Reverse Transcriptase Polymerase Chain Reaction Middle Aged Molecular biology Introns Microsatellite Female Human genome Geriatrics and Gerontology |
| Zdroj: | ResearcherID Scopus-Elsevier |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/61.6.547 |
| Popis: | The uneven distribution of Alu repetitive elements in the human genome is related to specific functional properties of genomic regions. We report the identification of a locus associated with human longevity in one of the chromosomal regions with the highest density of Alu elements, in 1p35. The locus, corresponding to a (TG)n microsatellite in the YTHDF2 gene, was identified by characterizing an ‘‘anonymous’’ marker detectable through interAlu fingerprinting, which previously evidenced an increased homozygosity in centenarians. After genotyping 412 participants of different ages, including 137 centenarians, we confirmed the increased homozygosity in centenarians at this locus, and observed a concomitantly increased frequency of the most frequent allele and the corresponding homozygous genotype. Remarkably, the same genotype was associated with increased YTHDF2 messenger RNA levels in immortalized lymphocytes. Finally, YTHDF2 messenger RNA resulted to be mainly expressed in testis and placenta. The data suggest a possible role of this locus in human longevity. |
| Databáze: | OpenAIRE |
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