The human squamous cervical carcinoma cell line, HOG-1, is responsive to steroid hormones
| Autor: | Shahid Pervez, J. E. Beesley, A. Jamil, R. P. Gleeson, R. N. Jones, William P Soutter, John O. White, J. D. Croxtall, L. Guida, Thomas Krausz |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Medroxyprogesterone Cancer Research medicine.medical_specialty medicine.drug_class medicine.medical_treatment Uterine Cervical Neoplasms Medroxyprogesterone Acetate Biology Steroid Internal medicine Tumor Cells Cultured medicine Humans Medroxyprogesterone acetate Endocrine system Estradiol Culture Media Tamoxifen Chemically defined medium Endocrinology Oncology Cell culture Estrogen Carcinoma Squamous Cell Female Cell Division medicine.drug Hormone |
| Zdroj: | International Journal of Cancer. 52:247-251 |
| ISSN: | 1097-0215 0020-7136 |
| Popis: | Growth of the human squamous cervical carcinoma cell line, HOG-1, was stimulated in response to oestradiol in serum-containing and chemically defined medium. The oestradiol-stimulated growth could be inhibited by 4-OH tamoxifen, progesterone and medroxyprogesterone acetate; the last 2 compounds also inhibited basal cell growth in serum-containing and chemically defined media. The data are consistent with the sensitivity of human squamous cervical cancer to sex-steroid hormones and suggest that endocrine therapies may be of benefit in this disease. © 1992 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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