Lack of association of platelet-derived growth factor (PDGF) receptor autoantibodies and severity of chronic graft-versus-host disease (GvHD)
| Autor: | Baerbel Spies-Weisshart, Frank Böhmer, Herbert G. Sayer, Andreas Hochhaus, Kristina Schilling, Sebastian Scholl |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Platelet-derived growth factor Graft vs Host Disease Autoantigens chemistry.chemical_compound Growth factor receptor immune system diseases Internal medicine medicine Humans Transplantation Homologous Receptors Platelet-Derived Growth Factor Receptor Autoantibodies Peripheral Blood Stem Cell Transplantation Hematology biology business.industry Autoantibody General Medicine medicine.disease Transplantation surgical procedures operative Graft-versus-host disease Oncology chemistry Chronic Disease Immunology biology.protein Female business Platelet-derived growth factor receptor |
| Zdroj: | Journal of Cancer Research and Clinical Oncology. 139:1397-1404 |
| ISSN: | 1432-1335 0171-5216 |
| DOI: | 10.1007/s00432-013-1451-z |
| Popis: | The existence of platelet-derived growth factor (PDGF) receptor autoantibodies in systemic sclerosis is conflicting, and such antibodies were also detected in patients with chronic graft-versus-host disease (GvHD) after allogeneic peripheral blood stem cell transplantation (PBSCT). We therefore aimed to screen for PDGF receptor autoantibodies in patients with chronic GvHD. We evaluated the existence of PDGF receptor autoantibodies in 39 patients, while 17 patients presented with a limited and 8 patients with an extensive chronic GvHD, respectively. Furthermore, 14 out of 39 patients had no chronic GvHD. We detected at least low levels of PDGF receptor autoantibodies in nearly all (35 of 39) patients after allogeneic PBSCT. Interestingly, only one of six patients with high levels of PDGF receptor autoantibodies presented with an extensive chronic GvHD, while the remaining six patients had no clinical signs of chronic GvHD. Thus, there was no correlation between the quantitative detection of antibodies directed against the PDGF receptor and the presence or severity of chronic GvHD. Platelet-derived growth factor receptor autoantibodies could easily be detected in patient sera. Nevertheless, we did not observe any correlation between the presence of PDGF receptor autoantibodies and the severity of chronic GvHD in patients who underwent allogeneic PBSCT. |
| Databáze: | OpenAIRE |
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