Associations between Body Mass Index and Chronic Kidney Disease in Type 2 Diabetes Mellitus Patients: Findings from the Northeast of Thailand
| Autor: | Muntasirur Rahman, Naznin Hossain, Sojib Bin Zaman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism 030204 cardiovascular system & hematology Overweight urologic and male genital diseases lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus medicine 030212 general & internal medicine Body mass index Kidney diseases lcsh:RC648-665 business.industry Type 2 Diabetes Mellitus nutritional and metabolic diseases Diabetes mellitus type 2 Odds ratio medicine.disease Obesity female genital diseases and pregnancy complications Obesity and Metabolic Syndrome Microalbuminuria Original Article medicine.symptom business Kidney disease |
| Zdroj: | Diabetes & Metabolism Journal, Vol 42, Iss 4, Pp 330-337 (2018) Diabetes & Metabolism Journal |
| ISSN: | 2233-6087 2233-6079 |
| Popis: | Background: Chronic kidney disease (CKD) has emerged as a public health burden globally. Obesity and long-term hyperglycaemia can initiate the renal vascular complications in patients with type 2 diabetes mellitus (T2DM). This study aimed to investigate the association of body mass index (BMI) with the CKD in patients with T2DM. Methods: This study has used retrospective medical records, biochemical reports, and anthropometric measurements of 3,580 T2DM patients which were collected between January to December 2015 from a district hospital in Thailand. CKD was defined according to the measurement of estimated glomerular filtration rate ( < 60 mL/min/1.73 m). Multiple logistic regression analysis was used to explore the association between BMI and CKD in patients with T2DM. Results: The mean age of the participants was 60.86±9.67 years, 53.68% had poor glycaemic control, and 45.21% were overweight. About one-in-four (23.26%) T2DM patients had CKD. The mean BMI of non-CKD group was slightly higher (25.30 kg/m vs. 24.30 kg/m) when compared with CKD patients. Multivariable analysis showed that older age, female sex, hypertension, and microalbuminuria were associated with the presence of CKD. No association was observed between CKD and poorly controlled glycosylated hemoglobin or hypercholesterolemia. Adjusted analysis further showed overweight and obesity were negatively associated with CKD (adjusted odds ratio [AOR], 0.73; 95% confidence interval [CI], 0.58 to 0.93) and (AOR, 0.53; 95% CI, 0.35 to 0.81), respectively. Conclusion: The negative association of BMI with CKD could reflect the reverse causality. Lower BMI might not lead a diabetic patient to develop CKD, but there are possibilities that CKD leads the patient to experience reduced BMI. |
| Databáze: | OpenAIRE |
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