Prenatal exposure to phthalates and its effects upon cognitive and motor functions : a systematic review

Autor: María Isabel Martínez-Martínez, Omar Cauli, Antoni Alegre-Martínez
Přispěvatelé: UCH. Departamento de Ciencias Biomédicas, Producción Científica UCH 2021
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
ISSN: 0300-483X
Popis: Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.sciencedirect.com/science/article/pii/S0300483X21003024?via%3Dihub Phthalates are chemicals widely used in packaging and consumer products, which have been shown to interfere with normal hormonal function and development in some human and animal studies. In recent decades, pregnant women’s exposure to phthalates has been shown to alter the cognitive outcomes of their babies, and some studies have found delays in motor development. Methods: electronic databases including PubMed/MEDLINE and Scopus were searched from their inception to March 2021, using the keywords "phthalate", "cognitive" and "motor". Results: most studies find statistically significant inverse relationships between maternal urinary phthalate concentration during pregnancy and subsequent outcomes in children’s cognitive and motor scales, especially in boys rather than girls. However, many associations are not significant, and there were even positive associations, especially in the third trimester. Conclusion: the relationship between exposure to phthalates during pregnancy and low results on neurocognitive scales is sufficiently clear to adopt policies to reduce exposure. Further studies are needed to analyze sex differences, coordination and motor scales, and phthalate levels during breastfeeding.
Databáze: OpenAIRE