Erratum. Elevated Serum Xanthine Oxidase Activity Is Associated With the Development of Type 2 Diabetes: A Prospective Cohort Study. Diabetes Care 2018;41;884-890
| Autor: | Xing Meng, Yanjiao Wang, Xiuyu Pang, Changhao Sun, Qiao Zhang, Xiaoyan Wu, Xinrui Deng, Ying Li, Xue Li, Xiangchun Gao |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Glucose Male Xanthine Oxidase medicine.medical_specialty Endocrinology Diabetes and Metabolism MEDLINE Type 2 diabetes Body Mass Index Elevated serum Sex Factors Diabetes mellitus Internal medicine Internal Medicine medicine Humans Insulin Prospective Studies Prospective cohort study Exercise Triglycerides Aged Proportional Hazards Models Glycated Hemoglobin Advanced and Specialized Nursing Errata business.industry Incidence Middle Aged medicine.disease Uric Acid Xanthine oxidase activity Cholesterol Cross-Sectional Studies Diabetes Mellitus Type 2 Female business |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 |
| Popis: | We aimed to evaluate whether xanthine oxidase (XO), a key enzyme in uric acid (UA) metabolism and a major source of reactive oxygen species, plays a causal and important role in the development of type 2 diabetes mellitus (T2DM) in a large prospective cohort study.A total of 4,412 diabetes-free adults (2,071 women and 2,341 men) aged 30-65 years at baseline in 2008 were involved. Participants were followed for incident change of glucose metabolism during an average of 4.7 years. At baseline, serum XO and UA, serum lipids, and glucose homeostasis indexes including fasting blood glucose (FBG), 2-h blood glucose (PBG), glycosylated hemoglobin ADuring an average follow-up period of 4.7 years, 249 women and 360 men developed new-onset T2DM. Serum XO activity was positively associated with UA concentration (allElevated serum XO activity, but not UA concentration, was associated with an increased risk of developing T2DM in women and men with mutual adjustment for XO and UA. Further studies are needed to examine the underlying mechanisms. |
| Databáze: | OpenAIRE |
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