A Comparison of the Efficacy of Various Metipranolol-Pilocarpine Combinations in Patients with Ocular Hypertension and Primary Open-Angle Glaucoma
| Autor: | Mordechai Sharir, S. F. Ball, Karanjit S. Kooner, R. G. Del Negro, Thom J. Zimmerman |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Intraocular pressure Open angle glaucoma Eye disease Glaucoma Ocular hypertension Placebo Double-Blind Method Ophthalmology medicine Humans Pharmacology (medical) Intraocular Pressure Aged Pharmacology business.industry Pilocarpine Middle Aged medicine.disease Metipranolol Anesthesia Drug Evaluation Drug Therapy Combination Female Ocular Hypertension Ophthalmic Solutions business Glaucoma Open-Angle medicine.drug |
| Zdroj: | Journal of Ocular Pharmacology and Therapeutics. 10:411-420 |
| ISSN: | 1557-7732 1080-7683 |
| Popis: | We compared the ocular hypotensive effects of four fixed-dose metipranolol-pilocarpine combinations in nineteen ocular hypertensive subjects and glaucoma patients. Each patient was tested with all of the study medications: vehicle alone, 0.1% metipranolol HCl + 2% pilocarpine HCl, 0.1% metipranolol HCl + 4% pilocarpine HCl, 0.3% metipranolol HCl + 2% pilocarpine HCl, and 0.3% metipranolol HCl + 4% pilocarpine HCl, in a single dose, randomized, double-masked, cross-over placebo-controlled trial. In addition, another eight age and baseline intraocular pressure (IOP)-matched subjects received 0.1% or 0.3% metipranolol HCl, while a similar group of 14 volunteers received 2% or 4% pilocarpine HCl. A two week washout period was instituted between the various groups of treatments. All four metipranolol-pilocarpine combinations were more effective than placebo or either medication alone in reducing the average IOP for up to 8 hours (p0.05 for each treatment group). Metipranolol HCl 0.3%, regardless of the pilocarpine concentration, demonstrated the most significant IOP lowering effect, reducing the IOP by 4.9 mm Hg or about 20% from baseline. However, 0.1% metipranolol HCl in combination with 4% pilocarpine HCl was found almost as effective with a 18.5% reduction in IOP from baseline, but a shorter duration of action. In conclusion, all metipranolol-pilocarpine combinations were more efficacious than either medication alone in a single-dose trial. Additional multiple-dose studies are needed to determine the long-term effectiveness and tolerance of combining 0.3% metipranolol HCl with either 2% or 4% pilocarpine HCl. |
| Databáze: | OpenAIRE |
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