Noradrenergic Activity in the Olfactory Bulb Is a Key Element for the Stability of Olfactory Memory
| Autor: | Christiane Linster, Anne Didier, Yohann Thenaisie, Christina Cho, Jeremy Forest, Nathalie Mandairon, Maellie Midroit, Marion Richard |
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| Přispěvatelé: | Cornell University [New York], Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS), Mandairon, Nathalie, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Acute effects Memory Long-Term [SDV]Life Sciences [q-bio] Male mice Reversal Learning Olfaction Stimulus (physiology) Optogenetics Biology Synaptic Transmission memory Mice Norepinephrine 03 medical and health sciences 0302 clinical medicine Reward Animals Computer Simulation Olfactory memory Research Articles ComputingMilieux_MISCELLANEOUS 030304 developmental biology Neurons 0303 health sciences computational General Neuroscience [SCCO.NEUR]Cognitive science/Neuroscience [SCCO.NEUR] Cognitive science/Neuroscience Olfactory Pathways Network dynamics Olfactory Bulb olfactory Olfactory bulb Mice Inbred C57BL Smell Odorants Synapses noradrenaline Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroscience Journal of Neuroscience, Society for Neuroscience, 2020, 40 (48), pp.9260-9271. ⟨10.1523/JNEUROSCI.1769-20.2020⟩ Journal of Neuroscience, Society for Neuroscience, 2020, pp.JN-RM-1769-20. ⟨10.1523/JNEUROSCI.1769-20.2020⟩ J Neurosci Journal of Neuroscience, 2020, 40 (48), pp.9260-9271. ⟨10.1523/JNEUROSCI.1769-20.2020⟩ |
| ISSN: | 0270-6474 1529-2401 |
| DOI: | 10.1523/JNEUROSCI.1769-20.2020⟩ |
| Popis: | Memory stability is essential for animal survival when environment and behavioral state change over short or long time spans. The stability of a memory can be expressed by its duration, its perseverance when conditions change as well as its specificity to the learned stimulus. Using optogenetic and pharmacological manipulations in male mice, we show that the presence of noradrenaline in the olfactory bulb during acquisition renders olfactory memories more stable. We show that while inhibition of noradrenaline transmission during an odor–reward acquisition has no acute effects, it alters perseverance, duration, and specificity of the memory. We use a computational approach to propose a proof of concept model showing that a single, simple network effect of noradrenaline on olfactory bulb dynamics can underlie these seemingly different behavioral effects. Our results show that acute changes in network dynamics can have long-term effects that extend beyond the network that was manipulated.SIGNIFICANCE STATEMENTOlfaction guides the behavior of animals. For successful survival, animals have to remember previously learned information and at the same time be able to acquire new memories. We show here that noradrenaline in the olfactory bulb, the first cortical relay of the olfactory information, is important for creating stable and specific olfactory memories. Memory stability, as expressed in perseverance, duration and specificity of the memory, is enhanced when noradrenergic inputs to the olfactory bulb are unaltered. We show that, computationally, our diverse behavioral results can be ascribed to noradrenaline-driven changes in neural dynamics. These results shed light on how very temporary changes in neuromodulation can have a variety of long-lasting effects on neural processing and behavior. |
| Databáze: | OpenAIRE |
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