Acute reproductive toxicology after intratesticular injection of silver nanoparticles (AgNPs) in Wistar rats

Autor:	Juliana Lis Mendes de Brito, Sergio Moya, Ricardo Bentes Azevedo, Paulo C. Morais, Dorleta Otaegui Ansa, Carolina Madeira Lucci, Vanessa Nicolau de Lima
Rok vydání:	2020
Předmět:	Male endocrine system Biodistribution Silver Reproductive toxicology Biomedical Engineering Metal Nanoparticles 02 engineering and technology 010501 environmental sciences Pharmacology Kidney Toxicology 01 natural sciences Silver nanoparticle Testis Animals Tissue Distribution Rats Wistar Sperm motility 0105 earth and related environmental sciences Epididymis Chemistry Reproduction Alanine Transaminase 021001 nanoscience & nanotechnology Spermatozoa Rats Liver Sperm morphology 0210 nano-technology Reproductive toxicity Spleen
Zdroj:	Nanotoxicology. 14:893-907
ISSN:	1743-5404 1743-5390
Popis:	This study aimed to evaluate the effects of an intratesticular injection of silver nanoparticles (AgNPs) on reproductive parameters and health of rats, and to evaluate the AgNPs biodistribution in order to develop a nanotechnological contraceptive agent for male animals. Treated animals received 220 μL of AgNPs solution (0.46 µg-Ag/ml) in each testicle and were euthanized: seven, 14, 28, and 56 days after injection. A significant decrease (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368b4d4dab024a4bb95c2d1f971eabc7 https://doi.org/10.1080/17435390.2020.1774812 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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