Pleofungins, Novel Inositol Phosphorylceramide Synthase Inhibitors, from Phoma sp. SANK 13899
| Autor: | Tatsuya Yano, Shiho Kozuma, Toshio Takatsu, Azusa Aoyagi |
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| Rok vydání: | 2007 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Magnetic Resonance Spectroscopy Chemical Phenomena Silylation Stereochemistry Acetic Anhydrides Molecular Conformation Alkalies Methylation Gas Chromatography-Mass Spectrometry Mass Spectrometry Hydrolysate chemistry.chemical_compound Ascomycota Depsipeptides Spectroscopy Fourier Transform Infrared Drug Discovery Inositol Enzyme Inhibitors Mycelium Pharmacology chemistry.chemical_classification Depsipeptide biology Chemistry Physical Antifungal antibiotic Hydrolysis Methanol biology.organism_classification Amino acid Hexosyltransferases chemistry Biochemistry Phoma |
| Zdroj: | The Journal of Antibiotics. 60:143-152 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.1038/ja.2007.14 |
| Popis: | Pleofungins (formerly called F-15078) A, B, C and D, novel depsipeptide antifungal antibiotics, were found in a mycelium extract of the producing fungus, Phoma sp. SANK 13899. The structures of pleofungins A, B, C and D were elucidated mainly by various NMR studies. The absolute configurations of the amino acids and N-methyl amino acids of pleofungin A constituents in the hydrolysate were determined by the application of advanced Marfey's method in combination with gas chromatography/mass spectrometry analysis of their silylation products with N-methyl-N-(tert-butylsilyl)trifluoroacetamide. Two alpha-hydroxy acid constituents, alpha-hydroxyisocaproic acid and alpha-hydroxyisovaleric acid, were isolated from the hydrolysate and their stereochemistries were determined by their specific rotations. |
| Databáze: | OpenAIRE |
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