Computational Analysis of Current and Noise Properties of a Single Open Ion Channel
| Autor: | Enrico Piccinini, Fabio Affinito, Rossella Brunetti, Massimo Rudan, Carlo Jacoboni |
|---|---|
| Přispěvatelé: | E. Piccinini, F. Affinito, R. Brunetti, C. Jacoboni, M. Rudan |
| Rok vydání: | 2006 |
| Předmět: |
Quantitative Biology::Biomolecules
Chemistry Monte Carlo method KcsA potassium channel Shot noise ion channels HISTOGRAM ANALYSIS METHOD Ion current Thermal conduction Noise (electronics) molecular dynamics electrical noise Computer Science Applications Molecular dynamics MOLECULAR-DYNAMICS CONDUCTION K+ CHANNEL Statistical physics Physical and Theoretical Chemistry FREE-ENERGY CALCULATIONS Communication channel |
| Zdroj: | Journal of chemical theory and computation 3 (2007): 248–255. info:cnr-pdr/source/autori:Piccinini, E; Affinito, F; Brunetti, R; Jacoboni, C; Rudan, M/titolo:Computational analysis of current and noise properties of a single open ion channel/doi:/rivista:Journal of chemical theory and computation/anno:2007/pagina_da:248/pagina_a:255/intervallo_pagine:248–255/volume:3 |
| ISSN: | 1549-9626 1549-9618 |
| DOI: | 10.1021/ct6002077 |
| Popis: | This paper presents a computational analysis of the noise associated with the ion current in single open ion channels. The study is performed by means of a coupled molecular dynamics/Monte Carlo approach able to simulate the onduction process on the basis of all microscopic information today available from protein structural data and atomistic simulations. The case of potassium ions permeating the KcsA channel is considered in the numerical calculations. The results show a noise spectrum different from what is theoretically predicted for Poisson noise, confirmed by the existence of a correlation in ion-exit events. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|